FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1592856437> ?p ?o ?g. }

• W1592856437 endingPage "206" @default.
• W1592856437 startingPage "197" @default.
• W1592856437 abstract "Background: Chronic alcohol ingestion increases the incidence and severity of the acute respiratory distress syndrome (ARDS), where reactive species contribute to alveolar‐capillary barrier dysfunction and noncardiogenic pulmonary edema. Previous studies demonstrated that chronic alcohol ingestion increased lung NADPH oxidase and endothelial nitric oxide synthase (eNOS) expression and that ligands for the peroxisome proliferator‐activated receptor gamma (PPARγ) reduced NADPH oxidase expression. Therefore, we hypothesized that the PPARγ ligand, rosiglitazone, would attenuate alcohol‐induced NADPH oxidase expression and pulmonary barrier dysfunction. Methods: C57Bl/6 mice were treated ± alcohol in drinking water (20% w/v) for 12 weeks. During the final week of alcohol treatment, mice were gavaged with rosiglitazone (10 mg/kg/d) or vehicle. Selected animals were treated twice with lipopolysaccharide (LPS, 2 mg/kg IP) prior to sacrifice. Pulmonary barrier dysfunction was estimated from protein content of bronchoalveolar lavage (BAL) fluid. Results: LPS treatment increased BAL protein in alcohol‐fed but not control mice, and rosiglitazone attenuated LPS and alcohol‐induced pulmonary barrier dysfunction. Alcohol‐ and LPS‐induced increases in lung eNOS, Nox1, and Nox4 expression were attenuated by rosiglitazone. In vitro, alcohol (0.10% w/v) increased H 2 O 2 production, barrier dysfunction, eNOS, Nox1, and Nox4 expression in human umbilical vein endothelial cell (HUVEC) monolayers, effects also attenuated by rosiglitazone (10 μM). Alcohol‐induced HUVEC barrier dysfunction was attenuated by inhibition of NOS or addition of the eNOS cofactor, tetrahydrobiopterin. Conclusions: These results indicate that PPARγ activation reduced expression of eNOS, Nox1, Nox4, the production of reactive species, and barrier dysfunction caused by chronic alcohol ingestion and suggest that PPARγ represents a novel therapeutic target for strategies designed to reduce the risk of lung injury in patients with a history of chronic alcohol ingestion." @default.
• W1592856437 created "2016-06-24" @default.
• W1592856437 creator A5000011187 @default.
• W1592856437 creator A5039718438 @default.
• W1592856437 creator A5044627146 @default.
• W1592856437 creator A5073349266 @default.
• W1592856437 date "2011-07-18" @default.
• W1592856437 modified "2023-10-02" @default.
• W1592856437 title "PPARγ Ligands Regulate NADPH Oxidase, eNOS, and Barrier Function in the Lung Following Chronic Alcohol Ingestion" @default.
• W1592856437 cites W1582022233 @default.
• W1592856437 cites W1672804368 @default.
• W1592856437 cites W1968703258 @default.
• W1592856437 cites W1972136146 @default.
• W1592856437 cites W1979638709 @default.
• W1592856437 cites W1982207882 @default.
• W1592856437 cites W1988711918 @default.
• W1592856437 cites W1990724339 @default.
• W1592856437 cites W1998174651 @default.
• W1592856437 cites W2008497553 @default.
• W1592856437 cites W2015124236 @default.
• W1592856437 cites W2024874163 @default.
• W1592856437 cites W2029160589 @default.
• W1592856437 cites W2047852384 @default.
• W1592856437 cites W2054727930 @default.
• W1592856437 cites W2062580238 @default.
• W1592856437 cites W2066757906 @default.
• W1592856437 cites W2067246993 @default.
• W1592856437 cites W2071077259 @default.
• W1592856437 cites W2085128107 @default.
• W1592856437 cites W2085722625 @default.
• W1592856437 cites W2087403378 @default.
• W1592856437 cites W2098132645 @default.
• W1592856437 cites W2099067020 @default.
• W1592856437 cites W2102602047 @default.
• W1592856437 cites W2103687576 @default.
• W1592856437 cites W2107914421 @default.
• W1592856437 cites W2110182057 @default.
• W1592856437 cites W2110361956 @default.
• W1592856437 cites W2113352661 @default.
• W1592856437 cites W2119043221 @default.
• W1592856437 cites W2119617266 @default.
• W1592856437 cites W2127125241 @default.
• W1592856437 cites W2128811495 @default.
• W1592856437 cites W2129707656 @default.
• W1592856437 cites W2132734354 @default.
• W1592856437 cites W2133516203 @default.
• W1592856437 cites W2134884703 @default.
• W1592856437 cites W2139551405 @default.
• W1592856437 cites W2140505663 @default.
• W1592856437 cites W2150442739 @default.
• W1592856437 cites W2153152135 @default.
• W1592856437 cites W2159969745 @default.
• W1592856437 cites W2164711738 @default.
• W1592856437 cites W2165073849 @default.
• W1592856437 cites W2172186754 @default.
• W1592856437 cites W2277780346 @default.
• W1592856437 cites W2290721442 @default.
• W1592856437 cites W2339811112 @default.
• W1592856437 cites W4240449862 @default.
• W1592856437 cites W4251464227 @default.
• W1592856437 cites W4294658238 @default.
• W1592856437 cites W71678318 @default.
• W1592856437 doi "https://doi.org/10.1111/j.1530-0277.2011.01599.x" @default.
• W1592856437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3197969" @default.
• W1592856437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21762184" @default.
• W1592856437 hasPublicationYear "2011" @default.
• W1592856437 type Work @default.
• W1592856437 sameAs 1592856437 @default.
• W1592856437 citedByCount "33" @default.
• W1592856437 countsByYear W15928564372012 @default.
• W1592856437 countsByYear W15928564372013 @default.
• W1592856437 countsByYear W15928564372014 @default.
• W1592856437 countsByYear W15928564372015 @default.
• W1592856437 countsByYear W15928564372016 @default.
• W1592856437 countsByYear W15928564372017 @default.
• W1592856437 countsByYear W15928564372019 @default.
• W1592856437 countsByYear W15928564372020 @default.
• W1592856437 countsByYear W15928564372021 @default.
• W1592856437 countsByYear W15928564372022 @default.
• W1592856437 countsByYear W15928564372023 @default.
• W1592856437 crossrefType "journal-article" @default.
• W1592856437 hasAuthorship W1592856437A5000011187 @default.
• W1592856437 hasAuthorship W1592856437A5039718438 @default.
• W1592856437 hasAuthorship W1592856437A5044627146 @default.
• W1592856437 hasAuthorship W1592856437A5073349266 @default.
• W1592856437 hasBestOaLocation W15928564372 @default.
• W1592856437 hasConcept C126322002 @default.
• W1592856437 hasConcept C134018914 @default.
• W1592856437 hasConcept C170493617 @default.
• W1592856437 hasConcept C185592680 @default.
• W1592856437 hasConcept C2776151105 @default.
• W1592856437 hasConcept C2776348555 @default.
• W1592856437 hasConcept C2777622882 @default.
• W1592856437 hasConcept C2777714996 @default.
• W1592856437 hasConcept C2777961210 @default.
• W1592856437 hasConcept C2778326061 @default.
• W1592856437 hasConcept C2779698670 @default.
• W1592856437 hasConcept C2779719074 @default.

• next