FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1592910307> ?p ?o ?g. }

• W1592910307 abstract "Cells from patients with Bloom's syndrome (BS), an autosomal recessive disorder associated with an increased risk of cancer, exhibit genomic instability. Increased numbers of sister-chromatid exchanges (SCE) and delayed DNA chain maturation are typically observed in BS cells. To elucidate the basis for the previously reported decreased DNA ligase I activity in BS cells, simultaneous immunoblot and activity assays for ligase-[32P]AMP adduct formation were performed on extracts from BS and normal lymphoblastoid cell lines. Immunoblot analysis using antibody to DNA ligase I indicate that the amount of the major reactive protein (98 kDa) in normal and BS cells is similar. However, a 50-90% decrease was observed in the ligase activity of the 98-kDa polypeptide in high-SCE BS cells (HG1514 and GM3403c). In contrast, the activity in low-SCE BS cells (HG1554) did not differ significantly from that in normal cells. The data, together with mixing experiments, indicate that the defect in BS ligase I is due at least in part to the loss of ATP binding and/or hydrolytic activity and not to differences in numbers of protein molecules or inhibitory substances. These results suggest that mutation of the DNA ligase I gene may account for the primary metabolic defect in BS." @default.
• W1592910307 created "2016-06-24" @default.
• W1592910307 creator A5013556140 @default.
• W1592910307 creator A5042197211 @default.
• W1592910307 date "1988-12-01" @default.
• W1592910307 modified "2023-10-05" @default.
• W1592910307 title "Defective DNA ligase I in Bloom's syndrome cells. Simultaneous analysis using immunoblotting and the ligase-[32P]AMP adduct assay." @default.
• W1592910307 cites W1511257425 @default.
• W1592910307 cites W1539778975 @default.
• W1592910307 cites W1539783650 @default.
• W1592910307 cites W1596559313 @default.
• W1592910307 cites W1604391934 @default.
• W1592910307 cites W1976757330 @default.
• W1592910307 cites W1977789378 @default.
• W1592910307 cites W1981247025 @default.
• W1592910307 cites W1986748567 @default.
• W1592910307 cites W1988077266 @default.
• W1592910307 cites W1988848347 @default.
• W1592910307 cites W2000636910 @default.
• W1592910307 cites W2006180092 @default.
• W1592910307 cites W2010531023 @default.
• W1592910307 cites W2025500077 @default.
• W1592910307 cites W2030354083 @default.
• W1592910307 cites W2031460204 @default.
• W1592910307 cites W2034329236 @default.
• W1592910307 cites W2043364265 @default.
• W1592910307 cites W2049778245 @default.
• W1592910307 cites W2054976028 @default.
• W1592910307 cites W2055960628 @default.
• W1592910307 cites W2057915905 @default.
• W1592910307 cites W2058381769 @default.
• W1592910307 cites W2065327430 @default.
• W1592910307 cites W2065419863 @default.
• W1592910307 cites W2067898803 @default.
• W1592910307 cites W2071723944 @default.
• W1592910307 cites W2079545000 @default.
• W1592910307 cites W2084388445 @default.
• W1592910307 cites W2091294838 @default.
• W1592910307 cites W2093130587 @default.
• W1592910307 cites W2126876913 @default.
• W1592910307 cites W2152527557 @default.
• W1592910307 cites W2316476374 @default.
• W1592910307 doi "https://doi.org/10.1016/s0021-9258(19)81350-9" @default.
• W1592910307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3192533" @default.
• W1592910307 hasPublicationYear "1988" @default.
• W1592910307 type Work @default.
• W1592910307 sameAs 1592910307 @default.
• W1592910307 citedByCount "25" @default.
• W1592910307 crossrefType "journal-article" @default.
• W1592910307 hasAuthorship W1592910307A5013556140 @default.
• W1592910307 hasAuthorship W1592910307A5042197211 @default.
• W1592910307 hasBestOaLocation W15929103071 @default.
• W1592910307 hasConcept C104317684 @default.
• W1592910307 hasConcept C134459356 @default.
• W1592910307 hasConcept C153911025 @default.
• W1592910307 hasConcept C161223559 @default.
• W1592910307 hasConcept C175114707 @default.
• W1592910307 hasConcept C185592680 @default.
• W1592910307 hasConcept C25602115 @default.
• W1592910307 hasConcept C2779013463 @default.
• W1592910307 hasConcept C552990157 @default.
• W1592910307 hasConcept C55493867 @default.
• W1592910307 hasConcept C67705224 @default.
• W1592910307 hasConcept C86803240 @default.
• W1592910307 hasConceptScore W1592910307C104317684 @default.
• W1592910307 hasConceptScore W1592910307C134459356 @default.
• W1592910307 hasConceptScore W1592910307C153911025 @default.
• W1592910307 hasConceptScore W1592910307C161223559 @default.
• W1592910307 hasConceptScore W1592910307C175114707 @default.
• W1592910307 hasConceptScore W1592910307C185592680 @default.
• W1592910307 hasConceptScore W1592910307C25602115 @default.
• W1592910307 hasConceptScore W1592910307C2779013463 @default.
• W1592910307 hasConceptScore W1592910307C552990157 @default.
• W1592910307 hasConceptScore W1592910307C55493867 @default.
• W1592910307 hasConceptScore W1592910307C67705224 @default.
• W1592910307 hasConceptScore W1592910307C86803240 @default.
• W1592910307 hasLocation W15929103071 @default.
• W1592910307 hasOpenAccess W1592910307 @default.
• W1592910307 hasPrimaryLocation W15929103071 @default.
• W1592910307 hasRelatedWork W1482342775 @default.
• W1592910307 hasRelatedWork W1500815708 @default.
• W1592910307 hasRelatedWork W1511257425 @default.
• W1592910307 hasRelatedWork W1539778975 @default.
• W1592910307 hasRelatedWork W1539783650 @default.
• W1592910307 hasRelatedWork W1574971610 @default.
• W1592910307 hasRelatedWork W1596559313 @default.
• W1592910307 hasRelatedWork W1604391934 @default.
• W1592910307 hasRelatedWork W1888784016 @default.
• W1592910307 hasRelatedWork W1988848347 @default.
• W1592910307 hasRelatedWork W2000636910 @default.
• W1592910307 hasRelatedWork W2007437374 @default.
• W1592910307 hasRelatedWork W2010531023 @default.
• W1592910307 hasRelatedWork W2010617938 @default.
• W1592910307 hasRelatedWork W2057915905 @default.
• W1592910307 hasRelatedWork W2091548466 @default.
• W1592910307 hasRelatedWork W2111924246 @default.
• W1592910307 hasRelatedWork W2128635872 @default.
• W1592910307 hasRelatedWork W2154690609 @default.
• W1592910307 hasRelatedWork W2332340283 @default.
• W1592910307 isParatext "false" @default.

• next