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- W1592947360 endingPage "832" @default.
- W1592947360 startingPage "817" @default.
- W1592947360 abstract "Background The authors calculated the effect size for post-operative analgesia of three additives, clonidine, neostigmine, and tramadol to bupivacaine, ropivacaine, or levobupivacaine used for single-dose caudal extradural blockade in children. Methods A meta-analysis was performed for three end points of efficacy: the increase of time until administration of analgesic drugs, the proportion of patients requiring analgesic drugs during the initial 24 post-operative hours, and the amounts of post-operative analgesic drugs. A Bayesian inference supporting direct statements about the probability of the magnitude of an effect was used to compare the effects size. Results Neostigmine increased the duration of analgesia by 9.96 h (95% confidence interval: 7.75 to 12.16), as compared with 3.68 h (2.65 to 4.7) with clonidine and 4.45 (2.84 to 6.07) with tramadol. There is a 95% probability that neostigmine increases the duration of post-operative analgesia by more than 8 h, clonidine by more than 2.8 h, and tramadol by more than 3.25 h, as compared with local anesthetics alone. The odds ratios for the proportion of patients requiring analgesic drugs were 0.22 [0.13 to 0.37] for clonidine and 0.28 [0.10 to 0.75] for neostigmine. With tramadol, there was no statistically significant difference. All three additives reduced the amounts of post-operative analgesic drugs. Neostigmine and tramadol increase the probability for post-operative nausea or vomiting (PONV). Conclusions Neostigmine provides the longest post-operative analgesia. With clonidine, the duration of analgesia is shorter and sedation is increased, but the probability for PONV could be decreased." @default.
- W1592947360 created "2016-06-24" @default.
- W1592947360 creator A5005336900 @default.
- W1592947360 creator A5012352840 @default.
- W1592947360 date "2012-02-07" @default.
- W1592947360 modified "2023-10-07" @default.
- W1592947360 title "Bayesian enhanced meta-analysis of post-operative analgesic efficacy of additives for caudal analgesia in children" @default.
- W1592947360 cites W1529701853 @default.
- W1592947360 cites W1607945995 @default.
- W1592947360 cites W1676528262 @default.
- W1592947360 cites W1791587479 @default.
- W1592947360 cites W185775143 @default.
- W1592947360 cites W1913109589 @default.
- W1592947360 cites W1939298252 @default.
- W1592947360 cites W1965302235 @default.
- W1592947360 cites W1966540872 @default.
- W1592947360 cites W1967862123 @default.
- W1592947360 cites W1968535715 @default.
- W1592947360 cites W1969144595 @default.
- W1592947360 cites W1972716494 @default.
- W1592947360 cites W1973825736 @default.
- W1592947360 cites W1974881776 @default.
- W1592947360 cites W1976330014 @default.
- W1592947360 cites W1978590203 @default.
- W1592947360 cites W1981114551 @default.
- W1592947360 cites W1985949691 @default.
- W1592947360 cites W1986215651 @default.
- W1592947360 cites W1989192858 @default.
- W1592947360 cites W1992885035 @default.
- W1592947360 cites W2003343400 @default.
- W1592947360 cites W2005142778 @default.
- W1592947360 cites W2008593223 @default.
- W1592947360 cites W2022868163 @default.
- W1592947360 cites W2025989558 @default.
- W1592947360 cites W2026801013 @default.
- W1592947360 cites W2031986421 @default.
- W1592947360 cites W2034967012 @default.
- W1592947360 cites W2035084892 @default.
- W1592947360 cites W2039812684 @default.
- W1592947360 cites W2040740212 @default.
- W1592947360 cites W2047968861 @default.
- W1592947360 cites W2049891044 @default.
- W1592947360 cites W2050318078 @default.
- W1592947360 cites W2057097485 @default.
- W1592947360 cites W2062284527 @default.
- W1592947360 cites W2065368498 @default.
- W1592947360 cites W2067308956 @default.
- W1592947360 cites W2069883382 @default.
- W1592947360 cites W2070697817 @default.
- W1592947360 cites W2074484173 @default.
- W1592947360 cites W2083132715 @default.
- W1592947360 cites W2085986762 @default.
- W1592947360 cites W2086353990 @default.
- W1592947360 cites W2089420555 @default.
- W1592947360 cites W2091144355 @default.
- W1592947360 cites W2093789474 @default.
- W1592947360 cites W2098939860 @default.
- W1592947360 cites W2102458110 @default.
- W1592947360 cites W2104356375 @default.
- W1592947360 cites W2106035183 @default.
- W1592947360 cites W2108628123 @default.
- W1592947360 cites W2111582085 @default.
- W1592947360 cites W2112482723 @default.
- W1592947360 cites W2118832368 @default.
- W1592947360 cites W2119360594 @default.
- W1592947360 cites W2121606613 @default.
- W1592947360 cites W2127540120 @default.
- W1592947360 cites W2129807639 @default.
- W1592947360 cites W2131400892 @default.
- W1592947360 cites W2134744958 @default.
- W1592947360 cites W2139835784 @default.
- W1592947360 cites W2141162363 @default.
- W1592947360 cites W2145082159 @default.
- W1592947360 cites W2150510807 @default.
- W1592947360 cites W2151390353 @default.
- W1592947360 cites W2152648802 @default.
- W1592947360 cites W2155371247 @default.
- W1592947360 cites W2156098321 @default.
- W1592947360 cites W2159146906 @default.
- W1592947360 cites W2162359910 @default.
- W1592947360 cites W2162704927 @default.
- W1592947360 cites W2169878395 @default.
- W1592947360 cites W2345974285 @default.
- W1592947360 cites W2400021656 @default.
- W1592947360 cites W2416828224 @default.
- W1592947360 cites W2991792334 @default.
- W1592947360 cites W4210298917 @default.
- W1592947360 cites W4235854797 @default.
- W1592947360 cites W4236206458 @default.
- W1592947360 cites W4242332699 @default.
- W1592947360 cites W4250058106 @default.
- W1592947360 cites W4297918764 @default.
- W1592947360 cites W4298209114 @default.
- W1592947360 doi "https://doi.org/10.1111/j.1399-6576.2012.02651.x" @default.
- W1592947360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22313028" @default.
- W1592947360 hasPublicationYear "2012" @default.
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