FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1592979071> ?p ?o ?g. }

• W1592979071 endingPage "e0133783" @default.
• W1592979071 startingPage "e0133783" @default.
• W1592979071 abstract "Background and Purpose Perihematomal edema (PHE) contributes to secondary brain damage and aggravates patient outcomes after intracerebral hemorrhage (ICH). MicroRNAs (miRNAs) are stable in circulation, and their unique expression profiles have fundamental roles in modulating vascular disease. The objective of this study was to test the hypothesis that altered miRNA levels are associated with PHE in ICH patients. Methods Hematoma and PHE volumes of ICH patients were measured on admission and in follow-up computed tomography scans. Whole-genome miRNA profiles of ICH patients and healthy controls were determined using the Exiqon miRCURY LNA Array, and validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Bioinformatics analysis investigated dysregulated miRNA target genes and the signaling pathways involved. Results We identified 55 miRNAs that were differentially expressed in ICH patients compared with normal controls, of which 54 were down-regulated and one was up-regulated. qRT-PCR confirmation showed decreases in miR-126 (0.63-fold), miR-146a (0.64-fold), miR-let-7a (0.50-fold), and miR-26a (0.54-fold) in ICH patients relative to controls. Serum miR-126, but not miR-146a, miR-let-7a or miR-26a, levels were significantly correlated with relative PHE volume on days 3–4 (r = −0.714; P<0.001) in patients with ICH. Conclusions ICH patients appear to have a specific miRNA expression profile. Low expression of miR-126 was positively correlated with the extent of PHE, suggesting it may have a pathogenic role in the development of PHE after ICH." @default.
• W1592979071 created "2016-06-24" @default.
• W1592979071 creator A5001800952 @default.
• W1592979071 creator A5030866369 @default.
• W1592979071 creator A5034133337 @default.
• W1592979071 creator A5049761910 @default.
• W1592979071 creator A5090261081 @default.
• W1592979071 date "2015-07-24" @default.
• W1592979071 modified "2023-10-06" @default.
• W1592979071 title "Association of Altered Serum MicroRNAs with Perihematomal Edema after Acute Intracerebral Hemorrhage" @default.
• W1592979071 cites W144423133 @default.
• W1592979071 cites W1947113872 @default.
• W1592979071 cites W1963993086 @default.
• W1592979071 cites W1971053086 @default.
• W1592979071 cites W1981194197 @default.
• W1592979071 cites W1996003447 @default.
• W1592979071 cites W1999272982 @default.
• W1592979071 cites W2015681531 @default.
• W1592979071 cites W2019355821 @default.
• W1592979071 cites W2026581189 @default.
• W1592979071 cites W2031054659 @default.
• W1592979071 cites W2047402120 @default.
• W1592979071 cites W2047493201 @default.
• W1592979071 cites W2052677441 @default.
• W1592979071 cites W2052874229 @default.
• W1592979071 cites W2060481603 @default.
• W1592979071 cites W2064933761 @default.
• W1592979071 cites W2065025152 @default.
• W1592979071 cites W2070507194 @default.
• W1592979071 cites W2075142878 @default.
• W1592979071 cites W2075860675 @default.
• W1592979071 cites W2079030291 @default.
• W1592979071 cites W2086721674 @default.
• W1592979071 cites W2089226777 @default.
• W1592979071 cites W2090147463 @default.
• W1592979071 cites W2094585602 @default.
• W1592979071 cites W2095293285 @default.
• W1592979071 cites W2103798426 @default.
• W1592979071 cites W2112758818 @default.
• W1592979071 cites W2129994868 @default.
• W1592979071 cites W2132862382 @default.
• W1592979071 cites W2163169629 @default.
• W1592979071 cites W2330235342 @default.
• W1592979071 doi "https://doi.org/10.1371/journal.pone.0133783" @default.
• W1592979071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4514469" @default.
• W1592979071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26207814" @default.
• W1592979071 hasPublicationYear "2015" @default.
• W1592979071 type Work @default.
• W1592979071 sameAs 1592979071 @default.
• W1592979071 citedByCount "32" @default.
• W1592979071 countsByYear W15929790712016 @default.
• W1592979071 countsByYear W15929790712017 @default.
• W1592979071 countsByYear W15929790712018 @default.
• W1592979071 countsByYear W15929790712019 @default.
• W1592979071 countsByYear W15929790712020 @default.
• W1592979071 countsByYear W15929790712021 @default.
• W1592979071 countsByYear W15929790712022 @default.
• W1592979071 countsByYear W15929790712023 @default.
• W1592979071 crossrefType "journal-article" @default.
• W1592979071 hasAuthorship W1592979071A5001800952 @default.
• W1592979071 hasAuthorship W1592979071A5030866369 @default.
• W1592979071 hasAuthorship W1592979071A5034133337 @default.
• W1592979071 hasAuthorship W1592979071A5049761910 @default.
• W1592979071 hasAuthorship W1592979071A5090261081 @default.
• W1592979071 hasBestOaLocation W15929790711 @default.
• W1592979071 hasConcept C104317684 @default.
• W1592979071 hasConcept C126322002 @default.
• W1592979071 hasConcept C141071460 @default.
• W1592979071 hasConcept C142724271 @default.
• W1592979071 hasConcept C145059251 @default.
• W1592979071 hasConcept C146304588 @default.
• W1592979071 hasConcept C150194340 @default.
• W1592979071 hasConcept C2777094939 @default.
• W1592979071 hasConcept C2777736543 @default.
• W1592979071 hasConcept C2779018089 @default.
• W1592979071 hasConcept C2779662492 @default.
• W1592979071 hasConcept C2780886150 @default.
• W1592979071 hasConcept C2780942790 @default.
• W1592979071 hasConcept C4692481 @default.
• W1592979071 hasConcept C54355233 @default.
• W1592979071 hasConcept C60644358 @default.
• W1592979071 hasConcept C71924100 @default.
• W1592979071 hasConcept C86803240 @default.
• W1592979071 hasConceptScore W1592979071C104317684 @default.
• W1592979071 hasConceptScore W1592979071C126322002 @default.
• W1592979071 hasConceptScore W1592979071C141071460 @default.
• W1592979071 hasConceptScore W1592979071C142724271 @default.
• W1592979071 hasConceptScore W1592979071C145059251 @default.
• W1592979071 hasConceptScore W1592979071C146304588 @default.
• W1592979071 hasConceptScore W1592979071C150194340 @default.
• W1592979071 hasConceptScore W1592979071C2777094939 @default.
• W1592979071 hasConceptScore W1592979071C2777736543 @default.
• W1592979071 hasConceptScore W1592979071C2779018089 @default.
• W1592979071 hasConceptScore W1592979071C2779662492 @default.
• W1592979071 hasConceptScore W1592979071C2780886150 @default.
• W1592979071 hasConceptScore W1592979071C2780942790 @default.
• W1592979071 hasConceptScore W1592979071C4692481 @default.
• W1592979071 hasConceptScore W1592979071C54355233 @default.

• next