FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1593011531> ?p ?o ?g. }

• W1593011531 endingPage "109" @default.
• W1593011531 startingPage "103" @default.
• W1593011531 abstract "Abstract Long chain fatty acids inhibit the Mg2+-dependent Na+ + K+-stimulated ATPase of rat brain microsomal membrane preparations without any significant effect on the basic Mg2+-stimulated component. The magnitude of inhibition increases with the chain length, reaching a maximum with myristate followed by a decline with higher fatty acids. Myristate (5 x 10-5 m) produces about 45% inhibition of the Na+ + K+-stimulated ATPase. Unsaturated fatty acids are more inhibitory than their corresponding saturated congeners; e.g. at 5 x 10-5 m, oleate produces 66% inhibition compared with 15% by stearate. The inhibitory effects are not due to the binding of Mg2+ by fatty acids as the effects are not reversed by increasing the Mg2+ concentration in the reaction. The inhibition is freely reversible and does not appear to be time dependent. Kinetic analysis of the action of myristate on the Na+ + K+-stimulated ATPase indicates that the inhibition is uncompetitive with respect to ATP and competitive with respect to K+. The primary site of action of myristate appears to be an inhibition of K+ activation of the enzyme. The Na+ activation of the enzyme is also inhibited, but only when the concentration of Na+ is very low; in the presence of higher concentrations of Na+, the action of myristate can be interpreted as a second (in addition to Na+) competitive inhibitor of K+. K+-stimulated p-nitrophenyl phosphatase is also inhibited in a competitive fashion by myristate. The myristate inhibition of the Na+ + K+-stimulated ATPase is as well elicited in the presence of ouabain or oligomycin. The effects of these mixed inhibitors are of a cumulative nature suggesting separate binding sites for each of the inhibitors." @default.
• W1593011531 created "2016-06-24" @default.
• W1593011531 creator A5005593638 @default.
• W1593011531 creator A5028679103 @default.
• W1593011531 creator A5090238458 @default.
• W1593011531 date "1971-01-01" @default.
• W1593011531 modified "2023-10-14" @default.
• W1593011531 title "The Effects of Long Chain Fatty Acids on Sodium Plus Potassium Ion-stimulated Adenosine Triphosphatase of Rat Brain" @default.
• W1593011531 cites W1586003981 @default.
• W1593011531 cites W1633337670 @default.
• W1593011531 cites W173506749 @default.
• W1593011531 cites W1775749144 @default.
• W1593011531 cites W1885778179 @default.
• W1593011531 cites W1967392735 @default.
• W1593011531 cites W1973935601 @default.
• W1593011531 cites W1975146678 @default.
• W1593011531 cites W1984363965 @default.
• W1593011531 cites W2016952012 @default.
• W1593011531 cites W2034335419 @default.
• W1593011531 cites W2051991390 @default.
• W1593011531 cites W2054979333 @default.
• W1593011531 cites W2058035181 @default.
• W1593011531 cites W2066666306 @default.
• W1593011531 cites W2068957735 @default.
• W1593011531 cites W2088515555 @default.
• W1593011531 cites W2089343169 @default.
• W1593011531 cites W2093120836 @default.
• W1593011531 cites W2108547497 @default.
• W1593011531 cites W2153435210 @default.
• W1593011531 cites W2309532548 @default.
• W1593011531 cites W2398939770 @default.
• W1593011531 cites W2410366896 @default.
• W1593011531 cites W2413701672 @default.
• W1593011531 cites W4249225370 @default.
• W1593011531 cites W58370825 @default.
• W1593011531 doi "https://doi.org/10.1016/s0021-9258(18)62538-4" @default.
• W1593011531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4250727" @default.
• W1593011531 hasPublicationYear "1971" @default.
• W1593011531 type Work @default.
• W1593011531 sameAs 1593011531 @default.
• W1593011531 citedByCount "176" @default.
• W1593011531 countsByYear W15930115312015 @default.
• W1593011531 countsByYear W15930115312016 @default.
• W1593011531 countsByYear W15930115312017 @default.
• W1593011531 countsByYear W15930115312021 @default.
• W1593011531 crossrefType "journal-article" @default.
• W1593011531 hasAuthorship W1593011531A5005593638 @default.
• W1593011531 hasAuthorship W1593011531A5028679103 @default.
• W1593011531 hasAuthorship W1593011531A5090238458 @default.
• W1593011531 hasBestOaLocation W15930115311 @default.
• W1593011531 hasConcept C145148216 @default.
• W1593011531 hasConcept C178790620 @default.
• W1593011531 hasConcept C181199279 @default.
• W1593011531 hasConcept C185592680 @default.
• W1593011531 hasConcept C23265538 @default.
• W1593011531 hasConcept C2776991684 @default.
• W1593011531 hasConcept C2779564974 @default.
• W1593011531 hasConcept C3018891471 @default.
• W1593011531 hasConcept C517785266 @default.
• W1593011531 hasConcept C537181965 @default.
• W1593011531 hasConcept C55493867 @default.
• W1593011531 hasConceptScore W1593011531C145148216 @default.
• W1593011531 hasConceptScore W1593011531C178790620 @default.
• W1593011531 hasConceptScore W1593011531C181199279 @default.
• W1593011531 hasConceptScore W1593011531C185592680 @default.
• W1593011531 hasConceptScore W1593011531C23265538 @default.
• W1593011531 hasConceptScore W1593011531C2776991684 @default.
• W1593011531 hasConceptScore W1593011531C2779564974 @default.
• W1593011531 hasConceptScore W1593011531C3018891471 @default.
• W1593011531 hasConceptScore W1593011531C517785266 @default.
• W1593011531 hasConceptScore W1593011531C537181965 @default.
• W1593011531 hasConceptScore W1593011531C55493867 @default.
• W1593011531 hasIssue "1" @default.
• W1593011531 hasLocation W15930115311 @default.
• W1593011531 hasOpenAccess W1593011531 @default.
• W1593011531 hasPrimaryLocation W15930115311 @default.
• W1593011531 hasRelatedWork W2063855007 @default.
• W1593011531 hasRelatedWork W2112214832 @default.
• W1593011531 hasRelatedWork W2123123125 @default.
• W1593011531 hasRelatedWork W2285794816 @default.
• W1593011531 hasRelatedWork W2314245732 @default.
• W1593011531 hasRelatedWork W2323677139 @default.
• W1593011531 hasRelatedWork W2473215621 @default.
• W1593011531 hasRelatedWork W2614668278 @default.
• W1593011531 hasRelatedWork W2733819444 @default.
• W1593011531 hasRelatedWork W2018302231 @default.
• W1593011531 hasVolume "246" @default.
• W1593011531 isParatext "false" @default.
• W1593011531 isRetracted "false" @default.
• W1593011531 magId "1593011531" @default.
• W1593011531 workType "article" @default.