FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1593203226> ?p ?o ?g. }

• W1593203226 endingPage "1480" @default.
• W1593203226 startingPage "1473" @default.
• W1593203226 abstract "Objective Progress in the prevention and treatment of women at risk of pre‐eclampsia (PE) still remains hindered by the lack of clinical screening tools that can accurately predict which mothers are at risk. The identification and validation of predictive biomarkers is therefore seen as a critical milestone towards improved healthcare provision and the clinical testing of new therapeutic strategies. Gel‐free proteomic technologies offer the capability of analysing hundreds of plasma proteins simultaneously, but as yet these methods have not been applied to pregnancy complications. To assess the feasibility of such an approach to plasma biomarker research in pregnancy we have applied the technique to samples from women with PE to gestation‐matched controls. Sample Pooled plasma samples taken at time of disease from women with PE ( n = 23) and gestation‐matched controls ( n = 23). Methods Proteomics strategy for relative quantification of proteins using mass spectrometry. Results We identified several differences, including elevated levels of endoglin, PAPP‐A and PSG1 in PE plasma. Increased levels of endoglin were validated using immunoassay analysis of individual plasma samples. Conclusions Although at a relatively early stage, this mass spectrometry‐based approach shows promise as a tool to identify global protein changes in plasma. The application of these methods to pre‐disease samples is the next step in the identification of clinically useful biomarkers." @default.
• W1593203226 created "2016-06-24" @default.
• W1593203226 creator A5039337111 @default.
• W1593203226 creator A5057588460 @default.
• W1593203226 creator A5064959070 @default.
• W1593203226 creator A5071823096 @default.
• W1593203226 creator A5076360005 @default.
• W1593203226 creator A5077345636 @default.
• W1593203226 date "2009-09-16" @default.
• W1593203226 modified "2023-10-17" @default.
• W1593203226 title "A proof-of-principle gel-free proteomics strategy for the identification of predictive biomarkers for the onset of pre-eclampsia" @default.
• W1593203226 cites W1584663400 @default.
• W1593203226 cites W1966956497 @default.
• W1593203226 cites W1975896592 @default.
• W1593203226 cites W1990795537 @default.
• W1593203226 cites W2003704973 @default.
• W1593203226 cites W2036540909 @default.
• W1593203226 cites W2045890236 @default.
• W1593203226 cites W2067735218 @default.
• W1593203226 cites W2084108911 @default.
• W1593203226 cites W2096142201 @default.
• W1593203226 cites W2104732966 @default.
• W1593203226 cites W2115129497 @default.
• W1593203226 cites W2117327695 @default.
• W1593203226 cites W2120006904 @default.
• W1593203226 cites W2121464784 @default.
• W1593203226 cites W2126750011 @default.
• W1593203226 cites W2133107827 @default.
• W1593203226 cites W2148365034 @default.
• W1593203226 cites W2157839186 @default.
• W1593203226 cites W2172116519 @default.
• W1593203226 cites W4236182870 @default.
• W1593203226 cites W4242472190 @default.
• W1593203226 doi "https://doi.org/10.1111/j.1471-0528.2009.02283.x" @default.
• W1593203226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19663911" @default.
• W1593203226 hasPublicationYear "2009" @default.
• W1593203226 type Work @default.
• W1593203226 sameAs 1593203226 @default.
• W1593203226 citedByCount "21" @default.
• W1593203226 countsByYear W15932032262012 @default.
• W1593203226 countsByYear W15932032262013 @default.
• W1593203226 countsByYear W15932032262014 @default.
• W1593203226 countsByYear W15932032262015 @default.
• W1593203226 countsByYear W15932032262018 @default.
• W1593203226 countsByYear W15932032262019 @default.
• W1593203226 countsByYear W15932032262021 @default.
• W1593203226 crossrefType "journal-article" @default.
• W1593203226 hasAuthorship W1593203226A5039337111 @default.
• W1593203226 hasAuthorship W1593203226A5057588460 @default.
• W1593203226 hasAuthorship W1593203226A5064959070 @default.
• W1593203226 hasAuthorship W1593203226A5071823096 @default.
• W1593203226 hasAuthorship W1593203226A5076360005 @default.
• W1593203226 hasAuthorship W1593203226A5077345636 @default.
• W1593203226 hasConcept C10205521 @default.
• W1593203226 hasConcept C104317684 @default.
• W1593203226 hasConcept C116834253 @default.
• W1593203226 hasConcept C126322002 @default.
• W1593203226 hasConcept C185592680 @default.
• W1593203226 hasConcept C2779134260 @default.
• W1593203226 hasConcept C2779234561 @default.
• W1593203226 hasConcept C2781197716 @default.
• W1593203226 hasConcept C2781276381 @default.
• W1593203226 hasConcept C28328180 @default.
• W1593203226 hasConcept C46111723 @default.
• W1593203226 hasConcept C46973012 @default.
• W1593203226 hasConcept C54355233 @default.
• W1593203226 hasConcept C55493867 @default.
• W1593203226 hasConcept C59822182 @default.
• W1593203226 hasConcept C6061869 @default.
• W1593203226 hasConcept C60644358 @default.
• W1593203226 hasConcept C71924100 @default.
• W1593203226 hasConcept C86803240 @default.
• W1593203226 hasConceptScore W1593203226C10205521 @default.
• W1593203226 hasConceptScore W1593203226C104317684 @default.
• W1593203226 hasConceptScore W1593203226C116834253 @default.
• W1593203226 hasConceptScore W1593203226C126322002 @default.
• W1593203226 hasConceptScore W1593203226C185592680 @default.
• W1593203226 hasConceptScore W1593203226C2779134260 @default.
• W1593203226 hasConceptScore W1593203226C2779234561 @default.
• W1593203226 hasConceptScore W1593203226C2781197716 @default.
• W1593203226 hasConceptScore W1593203226C2781276381 @default.
• W1593203226 hasConceptScore W1593203226C28328180 @default.
• W1593203226 hasConceptScore W1593203226C46111723 @default.
• W1593203226 hasConceptScore W1593203226C46973012 @default.
• W1593203226 hasConceptScore W1593203226C54355233 @default.
• W1593203226 hasConceptScore W1593203226C55493867 @default.
• W1593203226 hasConceptScore W1593203226C59822182 @default.
• W1593203226 hasConceptScore W1593203226C6061869 @default.
• W1593203226 hasConceptScore W1593203226C60644358 @default.
• W1593203226 hasConceptScore W1593203226C71924100 @default.
• W1593203226 hasConceptScore W1593203226C86803240 @default.
• W1593203226 hasIssue "11" @default.
• W1593203226 hasLocation W15932032261 @default.
• W1593203226 hasLocation W15932032262 @default.
• W1593203226 hasOpenAccess W1593203226 @default.
• W1593203226 hasPrimaryLocation W15932032261 @default.
• W1593203226 hasRelatedWork W1582701437 @default.
• W1593203226 hasRelatedWork W1908539276 @default.

• next