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• W159330596 abstract "Osteoarthritis (OA) is a significant and growing concern to a large segment of the population. Effective treatments for slowing or stopping the progression of the disease are not available despite a great deal of investment-backed effort on the part of academia, government, and the pharmaceutical industry. Target selection has been problematic. Progress may also have been hindered to some extent by the prevalent cartilage-centric view of OA. Significant clinical development challenges remain for novel therapeutics in this area. This review elaborates on the challenges of disease-modifying OA drug development and points out specific therapeutic intervention strategies recently tried or currently being pursued." @default.
• W159330596 created "2016-06-24" @default.
• W159330596 creator A5053032145 @default.
• W159330596 date "2013-02-01" @default.
• W159330596 modified "2023-10-13" @default.
• W159330596 title "Disease Modification" @default.
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• W159330596 doi "https://doi.org/10.1016/j.rdc.2012.10.006" @default.
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