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- W1593362009 abstract "Summary Background The potential of psoralen–narrowband ultraviolet B ( NBUVB ) photochemotherapy has been investigated in vitiligo. The present study aims to evaluate the efficacy of psoralen– NBUVB ( P ‐ NBUVB ) vs. NBUVB in vitiligo. Methods In a randomized study, 45 Indian patients (age above 13 years) with vitiligo involving more than 5% body surface area were randomly allocated to receive either NBUVB or P ‐ NBUVB treatment. Both groups received NBUVB exposure thrice weekly, with a total of 60 sessions. The extent of repigmentation achieved was calculated on the basis of Vitiligo Area Severity Index ( VASI ) scoring. Results Forty patients were available for analysis at the end of the study. The extent of repigmentation in the P ‐ NBUVB group was statistically significantly greater in face and neck ( P = 0.006, t ‐test) and hands ( P = 0.007, t ‐test) in comparison with the NBUVB group ( t ‐test). Percentage reduction in VASI scores was statistically significantly greater in the P ‐ NBUVB group (29.2% vs. 21.7%, P = 0.043, t ‐test). The response to P ‐ NBUVB therapy started earlier than the response to NBUVB . After excluding sunlight as a confounding factor, treatment response was also significantly better in the P ‐ NBUVB group ( P = 0.005). Conclusion Addition of psoralen increased the extent of repigmentation due to NBUVB therapy in vitiligo. Further studies are required to determine the long‐term efficacy and safety of P ‐ NBUVB ." @default.
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- W1593362009 date "2013-10-03" @default.
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- W1593362009 title "Psoralen-narrowband UVB phototherapy for the treatment of vitiligo in comparison to narrowband UVB alone" @default.
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- W1593362009 doi "https://doi.org/10.1111/phpp.12072" @default.
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