FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1593419930> ?p ?o ?g. }

• W1593419930 endingPage "244" @default.
• W1593419930 startingPage "236" @default.
• W1593419930 abstract "Summary Signal regulatory protein α (SIRPα/CD172a), expressed by myeloid cells including CD11b + dendritic cells, interacts with ubiquitously expressed CD47 to mediate cell–cell signalling and therefore, may be pivotal in the development of tolerance or immunity. We show that in mice deficient in CD47 (CD47 −/− ) the cellularity in gut‐associated lymphoid tissues is reduced by 50%. In addition, the frequency of CD11b + CD172a + dendritic cells is significantly reduced in the gut and mesenteric lymph nodes, but not in Peyer’s patches. Activation of ovalbumin (OVA)‐specific CD4 + T cells in the mesenteric lymph nodes after feeding OVA is reduced in CD47 −/− mice compared with wild‐type however, induction of oral tolerance is maintained. The addition of cholera toxin generated normal serum anti‐OVA IgG and IgA titres but resulted in reduced intestinal anti‐OVA IgA in CD47 −/− mice. Replacing the haematopoietic compartment in CD47 −/− mice with wild‐type cells restored neither the cellularity in gut‐associated lymphoid tissues nor the capacity to produce intestinal anti‐OVA IgA following immunization. This study demonstrates that CD47 signalling is dispensable for oral tolerance induction, whereas the expression of CD47 by non‐haematopoietic cells is required for intestinal IgA B‐cell responses. This suggests that differential CD4 T cell functions control tolerance and enterotoxin‐induced IgA immunity in the gut." @default.
• W1593419930 created "2016-06-24" @default.
• W1593419930 creator A5017676745 @default.
• W1593419930 creator A5042983784 @default.
• W1593419930 creator A5045843609 @default.
• W1593419930 creator A5048251367 @default.
• W1593419930 creator A5074267089 @default.
• W1593419930 date "2012-01-24" @default.
• W1593419930 modified "2023-10-16" @default.
• W1593419930 title "CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a maintained capacity to induce oral tolerance" @default.
• W1593419930 cites W1488290759 @default.
• W1593419930 cites W1556844269 @default.
• W1593419930 cites W1564559691 @default.
• W1593419930 cites W1925857700 @default.
• W1593419930 cites W1982998313 @default.
• W1593419930 cites W1991804457 @default.
• W1593419930 cites W1998470464 @default.
• W1593419930 cites W2002220495 @default.
• W1593419930 cites W2004458273 @default.
• W1593419930 cites W2014090417 @default.
• W1593419930 cites W2018971469 @default.
• W1593419930 cites W2026809196 @default.
• W1593419930 cites W2035965693 @default.
• W1593419930 cites W2039949492 @default.
• W1593419930 cites W2039961722 @default.
• W1593419930 cites W2045848719 @default.
• W1593419930 cites W2083359402 @default.
• W1593419930 cites W2085268869 @default.
• W1593419930 cites W2094807194 @default.
• W1593419930 cites W2101635856 @default.
• W1593419930 cites W2106905367 @default.
• W1593419930 cites W2121791329 @default.
• W1593419930 cites W2130633620 @default.
• W1593419930 cites W2132788895 @default.
• W1593419930 cites W2143038122 @default.
• W1593419930 cites W2150087633 @default.
• W1593419930 cites W2153049426 @default.
• W1593419930 cites W2156024443 @default.
• W1593419930 cites W2157830017 @default.
• W1593419930 cites W2163590547 @default.
• W1593419930 doi "https://doi.org/10.1111/j.1365-2567.2011.03536.x" @default.
• W1593419930 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3311046" @default.
• W1593419930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22070457" @default.
• W1593419930 hasPublicationYear "2012" @default.
• W1593419930 type Work @default.
• W1593419930 sameAs 1593419930 @default.
• W1593419930 citedByCount "17" @default.
• W1593419930 countsByYear W15934199302013 @default.
• W1593419930 countsByYear W15934199302014 @default.
• W1593419930 countsByYear W15934199302015 @default.
• W1593419930 countsByYear W15934199302016 @default.
• W1593419930 countsByYear W15934199302019 @default.
• W1593419930 crossrefType "journal-article" @default.
• W1593419930 hasAuthorship W1593419930A5017676745 @default.
• W1593419930 hasAuthorship W1593419930A5042983784 @default.
• W1593419930 hasAuthorship W1593419930A5045843609 @default.
• W1593419930 hasAuthorship W1593419930A5048251367 @default.
• W1593419930 hasAuthorship W1593419930A5074267089 @default.
• W1593419930 hasBestOaLocation W15934199301 @default.
• W1593419930 hasConcept C109159458 @default.
• W1593419930 hasConcept C126322002 @default.
• W1593419930 hasConcept C142724271 @default.
• W1593419930 hasConcept C181152851 @default.
• W1593419930 hasConcept C203014093 @default.
• W1593419930 hasConcept C2776946954 @default.
• W1593419930 hasConcept C2777702733 @default.
• W1593419930 hasConcept C2779237934 @default.
• W1593419930 hasConcept C2779341262 @default.
• W1593419930 hasConcept C2779720271 @default.
• W1593419930 hasConcept C2780104668 @default.
• W1593419930 hasConcept C28328180 @default.
• W1593419930 hasConcept C3019368612 @default.
• W1593419930 hasConcept C71924100 @default.
• W1593419930 hasConcept C86803240 @default.
• W1593419930 hasConcept C8891405 @default.
• W1593419930 hasConcept C95444343 @default.
• W1593419930 hasConceptScore W1593419930C109159458 @default.
• W1593419930 hasConceptScore W1593419930C126322002 @default.
• W1593419930 hasConceptScore W1593419930C142724271 @default.
• W1593419930 hasConceptScore W1593419930C181152851 @default.
• W1593419930 hasConceptScore W1593419930C203014093 @default.
• W1593419930 hasConceptScore W1593419930C2776946954 @default.
• W1593419930 hasConceptScore W1593419930C2777702733 @default.
• W1593419930 hasConceptScore W1593419930C2779237934 @default.
• W1593419930 hasConceptScore W1593419930C2779341262 @default.
• W1593419930 hasConceptScore W1593419930C2779720271 @default.
• W1593419930 hasConceptScore W1593419930C2780104668 @default.
• W1593419930 hasConceptScore W1593419930C28328180 @default.
• W1593419930 hasConceptScore W1593419930C3019368612 @default.
• W1593419930 hasConceptScore W1593419930C71924100 @default.
• W1593419930 hasConceptScore W1593419930C86803240 @default.
• W1593419930 hasConceptScore W1593419930C8891405 @default.
• W1593419930 hasConceptScore W1593419930C95444343 @default.
• W1593419930 hasIssue "3" @default.
• W1593419930 hasLocation W15934199301 @default.
• W1593419930 hasLocation W15934199302 @default.
• W1593419930 hasLocation W15934199303 @default.
• W1593419930 hasOpenAccess W1593419930 @default.

• next