FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W159342656> ?p ?o ?g. }

• W159342656 abstract "Recently we reported a cytoplasmic sodium overload to cause a severe osmotic oedema in Duchenne muscular dystrophy (DMD). Our results suggested that this dual overload of sodium ions and water precedes the dystrophic process and persists until fatty muscle degeneration is complete. The present paper addresses the questions as to whether these overloads are important for the pathogenesis of the disease, and if so, whether they can be treated. As a first step, we investigated the effects of various diuretic drugs on a cell model of DMD, i.e. rat diaphragm strips previously exposed to amphotericin B. We found that both carbonic anhydrase inhibitors and aldosterone antagonists were able to repolarise depolarised muscle fibres. Since carbonic anhydrase inhibitors are known to have acidifying effects and this might be detrimental to the ventilation of DMD patients, we mainly concentrated on the modern spironolactone derivative, eplerenone. This drug had a very high repolarizing power, the parameter considered by us as being most relevant for a beneficial effect. In a pilot study we administered this drug to a 22-yr-old female DMD patient who was bound to an electric wheelchair and has had no corticosteroid therapy before. Eplerenone decreased both cytoplasmic sodium and water overload and increased muscle strength and mobility. We conclude that eplerenone has beneficial effects on DMD muscle. In our opinion the cytoplasmic oedema is cytotoxic and should be treated before fatty degeneration takes place." @default.
• W159342656 created "2016-06-24" @default.
• W159342656 creator A5035620085 @default.
• W159342656 creator A5039470281 @default.
• W159342656 creator A5041978982 @default.
• W159342656 creator A5045210310 @default.
• W159342656 creator A5070246576 @default.
• W159342656 creator A5073901105 @default.
• W159342656 creator A5090322200 @default.
• W159342656 date "2012-05-01" @default.
• W159342656 modified "2023-10-16" @default.
• W159342656 title "Rationale for treating oedema in Duchenne muscular dystrophy with eplerenone." @default.
• W159342656 cites W123131882 @default.
• W159342656 cites W1527832856 @default.
• W159342656 cites W1964890302 @default.
• W159342656 cites W1967406243 @default.
• W159342656 cites W1981856602 @default.
• W159342656 cites W1983073011 @default.
• W159342656 cites W1986350298 @default.
• W159342656 cites W2006437139 @default.
• W159342656 cites W2015985405 @default.
• W159342656 cites W2024824460 @default.
• W159342656 cites W2040786304 @default.
• W159342656 cites W2041938024 @default.
• W159342656 cites W2049031810 @default.
• W159342656 cites W2118987197 @default.
• W159342656 cites W2121206484 @default.
• W159342656 cites W2140357699 @default.
• W159342656 cites W2142307866 @default.
• W159342656 cites W2156880363 @default.
• W159342656 cites W2159394621 @default.
• W159342656 cites W2159422807 @default.
• W159342656 cites W2170113769 @default.
• W159342656 cites W2174903051 @default.
• W159342656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3440802" @default.
• W159342656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22655515" @default.
• W159342656 hasPublicationYear "2012" @default.
• W159342656 type Work @default.
• W159342656 sameAs 159342656 @default.
• W159342656 citedByCount "10" @default.
• W159342656 countsByYear W1593426562012 @default.
• W159342656 countsByYear W1593426562014 @default.
• W159342656 countsByYear W1593426562015 @default.
• W159342656 countsByYear W1593426562016 @default.
• W159342656 countsByYear W1593426562017 @default.
• W159342656 countsByYear W1593426562019 @default.
• W159342656 countsByYear W1593426562021 @default.
• W159342656 countsByYear W1593426562023 @default.
• W159342656 crossrefType "journal-article" @default.
• W159342656 hasAuthorship W159342656A5035620085 @default.
• W159342656 hasAuthorship W159342656A5039470281 @default.
• W159342656 hasAuthorship W159342656A5041978982 @default.
• W159342656 hasAuthorship W159342656A5045210310 @default.
• W159342656 hasAuthorship W159342656A5070246576 @default.
• W159342656 hasAuthorship W159342656A5073901105 @default.
• W159342656 hasAuthorship W159342656A5090322200 @default.
• W159342656 hasConcept C126322002 @default.
• W159342656 hasConcept C134018914 @default.
• W159342656 hasConcept C142724271 @default.
• W159342656 hasConcept C2776379505 @default.
• W159342656 hasConcept C2777017193 @default.
• W159342656 hasConcept C2778525890 @default.
• W159342656 hasConcept C2778943923 @default.
• W159342656 hasConcept C2780072264 @default.
• W159342656 hasConcept C71924100 @default.
• W159342656 hasConcept C98274493 @default.
• W159342656 hasConceptScore W159342656C126322002 @default.
• W159342656 hasConceptScore W159342656C134018914 @default.
• W159342656 hasConceptScore W159342656C142724271 @default.
• W159342656 hasConceptScore W159342656C2776379505 @default.
• W159342656 hasConceptScore W159342656C2777017193 @default.
• W159342656 hasConceptScore W159342656C2778525890 @default.
• W159342656 hasConceptScore W159342656C2778943923 @default.
• W159342656 hasConceptScore W159342656C2780072264 @default.
• W159342656 hasConceptScore W159342656C71924100 @default.
• W159342656 hasConceptScore W159342656C98274493 @default.
• W159342656 hasLocation W1593426561 @default.
• W159342656 hasOpenAccess W159342656 @default.
• W159342656 hasPrimaryLocation W1593426561 @default.
• W159342656 hasRelatedWork W1976430496 @default.
• W159342656 hasRelatedWork W2015985405 @default.
• W159342656 hasRelatedWork W2018069959 @default.
• W159342656 hasRelatedWork W2026065825 @default.
• W159342656 hasRelatedWork W2029384234 @default.
• W159342656 hasRelatedWork W2030020451 @default.
• W159342656 hasRelatedWork W2036563539 @default.
• W159342656 hasRelatedWork W2051863380 @default.
• W159342656 hasRelatedWork W2069526546 @default.
• W159342656 hasRelatedWork W2082423196 @default.
• W159342656 hasRelatedWork W2144956784 @default.
• W159342656 hasRelatedWork W2163925133 @default.
• W159342656 hasRelatedWork W2164481873 @default.
• W159342656 hasRelatedWork W2274096517 @default.
• W159342656 hasRelatedWork W2409884047 @default.
• W159342656 hasRelatedWork W2466547691 @default.
• W159342656 hasRelatedWork W2469400383 @default.
• W159342656 hasRelatedWork W2582167465 @default.
• W159342656 hasRelatedWork W3033059769 @default.
• W159342656 hasRelatedWork W2185774354 @default.
• W159342656 isParatext "false" @default.

• next