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- W159351467 abstract "Publisher Summary This chapter describes the diabetic neuropathy, one of the most common and debilitating effects of diabetes, and reviews nerve fiber pathology in human and experimental diabetic neuropathy. The chapter discusses the different ways that exaggerated polyol pathway flux, oxidative stress, increased advanced glycosylation end product formation, and deficient neurotrophic support compromise Schwann cells and the axons they ensheath. The chapter concludes that reported nerve fiber pathology resulting from diabetes mellitus ranges from subtle Schwann cell changes and axonal atrophy to complete fiber degeneration. Sensitivity of myelinated fiber injury to aldose reductase inhibition suggests a link to exaggerated polyol pathway flux in Schwann cells, vessels, and target tissue. Current thought emphasizes the role of oxidative stress, enhanced by polyol pathway activity and advanced glycation end product formation, in the vascular dysfunction of the early metabolic phase of human and experimental diabetic neuropathy. The sensitivity of markers of oxidative stress and antioxidant defense mechanisms to aldose reductase inhibition highlights the potential contribution of oxidative stress to the Schwann cell injury characteristic of human and experimental diabetic neuropathy." @default.
- W159351467 created "2016-06-24" @default.
- W159351467 creator A5032340487 @default.
- W159351467 date "2003-01-01" @default.
- W159351467 modified "2023-09-26" @default.
- W159351467 title "Schwann cells in diabetic neuropathy" @default.
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- W159351467 doi "https://doi.org/10.1016/s1569-2558(03)31050-1" @default.
- W159351467 hasPublicationYear "2003" @default.
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