Matches in SemOpenAlex for { <https://semopenalex.org/work/W1593519904> ?p ?o ?g. }
- W1593519904 endingPage "4382" @default.
- W1593519904 startingPage "4374" @default.
- W1593519904 abstract "The levels of the regulatory (RI and RII) and catalytic (C) components of cAMP-dependent protein kinase and of their messages were studied during the first 36 h of liver regeneration after 70% hepatectomy. Both RI α mRNA and RII α mRNA started to increase 4 h after the resection, reaching peak levels after 9 h. RI mRNA decreased abruptly 9–12 h after resection, whereas RII mRNA stayed elevated. C α mRNA was rather constant during the period of study. In accordance with the mRNA data the level of C was constant while RI and RII increased during the prereplicative phase of liver regeneration. RI increased rapidly when its message became elevated. RII, however, increased noticeably only 6–8 h after its mRNA had become elevated. The increased expression of R led to a disproportion between R and C that was most pronounced 14 h after resection, i.e. coinciding with the prereplicative cAMP burst. The increased R/C ratio at that time of regeneration diminished the concentration of active C subunit during the cAMP burst. In that way the otherwise inhibitory effect of high concentrations of active C on the DNA replication may have been decreased. The fractional saturation of RI and RII by endogenous cAMP fluctuated in parallel as a function of liver cAMP levels, although there was a tendency that RI was more highly saturated than RII at high concentrations of cAMP." @default.
- W1593519904 created "2016-06-24" @default.
- W1593519904 creator A5004806760 @default.
- W1593519904 creator A5007665730 @default.
- W1593519904 creator A5031838194 @default.
- W1593519904 creator A5033799076 @default.
- W1593519904 creator A5037636304 @default.
- W1593519904 creator A5064094413 @default.
- W1593519904 creator A5066573040 @default.
- W1593519904 creator A5069692170 @default.
- W1593519904 creator A5075880630 @default.
- W1593519904 creator A5077996961 @default.
- W1593519904 date "1989-03-01" @default.
- W1593519904 modified "2023-10-18" @default.
- W1593519904 title "The expression of cAMP-dependent protein kinase subunits is differentially regulated during liver regeneration" @default.
- W1593519904 cites W1121582380 @default.
- W1593519904 cites W1451751071 @default.
- W1593519904 cites W1488557950 @default.
- W1593519904 cites W1500961850 @default.
- W1593519904 cites W1506397261 @default.
- W1593519904 cites W1508175837 @default.
- W1593519904 cites W1509371349 @default.
- W1593519904 cites W1527409442 @default.
- W1593519904 cites W1532727976 @default.
- W1593519904 cites W1537203265 @default.
- W1593519904 cites W1542995590 @default.
- W1593519904 cites W1552240535 @default.
- W1593519904 cites W1559425094 @default.
- W1593519904 cites W1573237423 @default.
- W1593519904 cites W1576381397 @default.
- W1593519904 cites W1592393761 @default.
- W1593519904 cites W160527784 @default.
- W1593519904 cites W1607359458 @default.
- W1593519904 cites W1623130590 @default.
- W1593519904 cites W1625449763 @default.
- W1593519904 cites W182923797 @default.
- W1593519904 cites W1849948584 @default.
- W1593519904 cites W189649489 @default.
- W1593519904 cites W1954353020 @default.
- W1593519904 cites W1966652159 @default.
- W1593519904 cites W1967595735 @default.
- W1593519904 cites W1970042526 @default.
- W1593519904 cites W1975571138 @default.
- W1593519904 cites W1985374456 @default.
- W1593519904 cites W1987046671 @default.
- W1593519904 cites W1993187734 @default.
- W1593519904 cites W2001382445 @default.
- W1593519904 cites W2002955162 @default.
- W1593519904 cites W2004183888 @default.
- W1593519904 cites W2004917770 @default.
- W1593519904 cites W2007084890 @default.
- W1593519904 cites W2010084232 @default.
- W1593519904 cites W2010981679 @default.
- W1593519904 cites W2014669590 @default.
- W1593519904 cites W2023833056 @default.
- W1593519904 cites W2024273619 @default.
- W1593519904 cites W2031927989 @default.
- W1593519904 cites W2032941942 @default.
- W1593519904 cites W2036098036 @default.
- W1593519904 cites W2040529685 @default.
- W1593519904 cites W2043543206 @default.
- W1593519904 cites W2045650911 @default.
- W1593519904 cites W2045811908 @default.
- W1593519904 cites W2051699208 @default.
- W1593519904 cites W2052405585 @default.
- W1593519904 cites W2059735206 @default.
- W1593519904 cites W2060333964 @default.
- W1593519904 cites W2060918407 @default.
- W1593519904 cites W2064741419 @default.
- W1593519904 cites W2100837269 @default.
- W1593519904 cites W2109728108 @default.
- W1593519904 cites W2147727142 @default.
- W1593519904 cites W2155798958 @default.
- W1593519904 cites W2202507091 @default.
- W1593519904 cites W2219950861 @default.
- W1593519904 cites W2251920431 @default.
- W1593519904 cites W2261214409 @default.
- W1593519904 cites W2401578650 @default.
- W1593519904 cites W2418926412 @default.
- W1593519904 cites W2494331954 @default.
- W1593519904 cites W4293247451 @default.
- W1593519904 cites W935228828 @default.
- W1593519904 cites W1995311643 @default.
- W1593519904 doi "https://doi.org/10.1016/s0021-9258(18)83752-8" @default.
- W1593519904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2538442" @default.
- W1593519904 hasPublicationYear "1989" @default.
- W1593519904 type Work @default.
- W1593519904 sameAs 1593519904 @default.
- W1593519904 citedByCount "46" @default.
- W1593519904 countsByYear W15935199042013 @default.
- W1593519904 crossrefType "journal-article" @default.
- W1593519904 hasAuthorship W1593519904A5004806760 @default.
- W1593519904 hasAuthorship W1593519904A5007665730 @default.
- W1593519904 hasAuthorship W1593519904A5031838194 @default.
- W1593519904 hasAuthorship W1593519904A5033799076 @default.
- W1593519904 hasAuthorship W1593519904A5037636304 @default.
- W1593519904 hasAuthorship W1593519904A5064094413 @default.
- W1593519904 hasAuthorship W1593519904A5066573040 @default.