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• W1593570389 endingPage "121" @default.
• W1593570389 startingPage "112" @default.
• W1593570389 abstract "Proteasomes have been implicated in the production of the majority of peptides that associate with MHC class I molecules. We used two different proteasome inhibitors, the peptide aldehyde N-acetyl-L-leucyl-L-leucyl-L-norleucinal (LLnL) and the highly specific inhibitor lactacystin, to examine the role of proteasomes in generating peptide epitopes associated with HLA-A*0201. Neither LLnL nor lactacystin was able to completely block the expression of the HLA-A*0201. Furthermore, the effects of LLnL and lactacystin on the expression of different categories of specific epitopes, TAP independent vs TAP dependent and derived from either cytosolic or membrane proteins, were assessed. As predicted, presentation of two TAP-dependent epitopes was blocked by LLnL and lactacystin, while a TAP-independent epitope that is processed in the endoplasmic reticulum was unaffected by either inhibitor. Surprisingly, both LLnL and lactacystin increased rather than inhibited the expression of a cytosolically transcribed and TAP-dependent peptide from the influenza A virus M1 protein. Mass spectrometric analyses of in vitro proteasome digests of a synthetic 24 mer containing this epitope revealed no digestion products of any length that included the intact epitope. Instead, the major species resulted from cleavage sites within the epitope. Although cleavage at these sites was inhibitable by LLnL and lactacystin, epitope-containing species were still not produced. We conclude that proteasomes may in some cases actually destroy epitopes that would otherwise be destined for presentation by class I molecules. These results suggest that some epitopes are generated by nonproteasomal proteases in the cytosol." @default.
• W1593570389 created "2016-06-24" @default.
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• W1593570389 date "1998-07-01" @default.
• W1593570389 modified "2023-10-18" @default.
• W1593570389 title "Proteasomes Can Either Generate or Destroy MHC Class I Epitopes: Evidence for Nonproteasomal Epitope Generation in the Cytosol" @default.
• W1593570389 cites W1483817335 @default.
• W1593570389 cites W1494978663 @default.
• W1593570389 cites W1537166599 @default.
• W1593570389 cites W1573281914 @default.
• W1593570389 cites W1579770523 @default.
• W1593570389 cites W1589281113 @default.
• W1593570389 cites W1608231811 @default.
• W1593570389 cites W1626196218 @default.
• W1593570389 cites W1671456021 @default.
• W1593570389 cites W1672802330 @default.
• W1593570389 cites W1896681525 @default.
• W1593570389 cites W1902026954 @default.
• W1593570389 cites W1907471172 @default.
• W1593570389 cites W1927666148 @default.
• W1593570389 cites W1956554409 @default.
• W1593570389 cites W1967219468 @default.
• W1593570389 cites W1968330653 @default.
• W1593570389 cites W1977889843 @default.
• W1593570389 cites W1980443572 @default.
• W1593570389 cites W1981961617 @default.
• W1593570389 cites W1988645175 @default.
• W1593570389 cites W1991731171 @default.
• W1593570389 cites W1991840178 @default.
• W1593570389 cites W1997215036 @default.
• W1593570389 cites W2008744347 @default.
• W1593570389 cites W2020900160 @default.
• W1593570389 cites W2021289499 @default.
• W1593570389 cites W2022330696 @default.
• W1593570389 cites W2022717713 @default.
• W1593570389 cites W2024023167 @default.
• W1593570389 cites W2024050392 @default.
• W1593570389 cites W2025232842 @default.
• W1593570389 cites W2025990704 @default.
• W1593570389 cites W2028318264 @default.
• W1593570389 cites W2033531531 @default.
• W1593570389 cites W2035327851 @default.
• W1593570389 cites W2037260212 @default.
• W1593570389 cites W2037612991 @default.
• W1593570389 cites W2039658230 @default.
• W1593570389 cites W2040874036 @default.
• W1593570389 cites W2042285023 @default.
• W1593570389 cites W2044005280 @default.
• W1593570389 cites W2044070030 @default.
• W1593570389 cites W2047351190 @default.
• W1593570389 cites W2053044334 @default.
• W1593570389 cites W2053597753 @default.
• W1593570389 cites W2056665961 @default.
• W1593570389 cites W2061452227 @default.
• W1593570389 cites W2064387674 @default.
• W1593570389 cites W2066284211 @default.
• W1593570389 cites W2070316569 @default.
• W1593570389 cites W2077147012 @default.
• W1593570389 cites W2077861376 @default.
• W1593570389 cites W2081797035 @default.
• W1593570389 cites W2084416493 @default.
• W1593570389 cites W2091918298 @default.
• W1593570389 cites W2092725115 @default.
• W1593570389 cites W2096535057 @default.
• W1593570389 cites W2102683915 @default.
• W1593570389 cites W2104710873 @default.
• W1593570389 cites W2107312415 @default.
• W1593570389 cites W2110241531 @default.
• W1593570389 cites W2115470173 @default.
• W1593570389 cites W2117129326 @default.
• W1593570389 cites W2119184227 @default.
• W1593570389 cites W2120580958 @default.
• W1593570389 cites W2121076324 @default.
• W1593570389 cites W2125662108 @default.
• W1593570389 cites W2125913713 @default.
• W1593570389 cites W2129443680 @default.
• W1593570389 cites W2135854380 @default.
• W1593570389 cites W2163595408 @default.
• W1593570389 cites W2169840688 @default.
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• W1593570389 doi "https://doi.org/10.4049/jimmunol.161.1.112" @default.
• W1593570389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9647214" @default.
• W1593570389 hasPublicationYear "1998" @default.
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