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- W1593662922 abstract "Clinical response and changes in plasma testosterone were measured in 22 hirsute women during the administration of dexamethasone, ethinyl estradiol-medroxyprogesterone, or both. The response of plasma testosterone to the administration of adrenocorticotropic hormone (ACTH), human chorionic gonadotropin (HCG) and dexamethasone was measured before treatment in 16 patients, and six additional patients were treated without initial testing. Patients were treated with three month courses of each therapy, regardless of their test results. Results of short-term testing did not correlate with those of long-term treatment. Previously elevated testosterone levels were suppressed in 80 per cent of the patients treated with dexamethasone and in all the patients treated with ethinyl estradiol-medroxyprogesterone (EE-MP). Hirsutism diminished in a third of the patients treated with dexamethasone and in half of the patients treated with EE-MP. Acne diminished in half of the patients with either therapy. There was good correlation between normalization of plasma testosterone levels and clinical improvement. Normal plasma testosterone levels were maintained for several months after dexamethasone treatment was discontinued. Recommendations are given for the approach to diagnosis and treatment of the female patient with hirsutism." @default.
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- W1593662922 date "1973-02-01" @default.
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- W1593662922 title "Plasma testosterone stimulation-suppression dynamics in hirsute women" @default.
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- W1593662922 doi "https://doi.org/10.1016/0002-9343(73)90223-4" @default.
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