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• W1593710100 abstract "Summary Phosducin‐like proteins are conserved regulatory components of G‐protein signalling pathways, which mediate many physiological processes. Identified throughout eukaryotic genomes, they are thought to serve as regulators of Gβγ assembly. Cryphonectria parasitica , a plant pathogen and causative agent of chestnut blight, contains three Gα, one Gβ, one Gγ subunits and phosducin‐like protein BDM‐1 that have important roles in pigmentation, sporulation and virulence. Deletion of either Gβ subunit or BDM‐1 produces identical phenotypes. Additionally, we report that the Gβ subunit is not detectable in absence of BDM‐1. Given that the regulatory role of phosducin‐like proteins may be influenced by protein kinase 2 (CK2), we confirmed that BDM‐1 is a phosphoprotein that can be targeted by CK2 in vitro . Mutagenesis of the five putative CK2 sites revealed that native phosphorylation likely occurs at two locations. Strains bearing a single or double serine to alanine substitutions at those sites were significantly less virulent with only minor phenotypic changes from vegetative colonies. Therefore, CK2 activity appears to mediate key signals that are required for virulence, but not for vegetative growth. Expression of selected CK2 mutants resulted in reduced accumulation of the Gβ subunit, suggesting that phosphorylation of BDM‐1 influences Gβ stability." @default.
• W1593710100 created "2016-06-24" @default.
• W1593710100 creator A5006018755 @default.
• W1593710100 creator A5034713158 @default.
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• W1593710100 date "2010-05-01" @default.
• W1593710100 modified "2023-10-16" @default.
• W1593710100 title "Phosphorylation of phosducin-like protein BDM-1 by protein kinase 2 (CK2) is required for virulence and Gβ subunit stability in the fungal plant pathogen Cryphonectria parasitica" @default.
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• W1593710100 doi "https://doi.org/10.1111/j.1365-2958.2010.07053.x" @default.
• W1593710100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881307" @default.
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