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• W1593760300 endingPage "357" @default.
• W1593760300 startingPage "352" @default.
• W1593760300 abstract "The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, interleukin 1β (IL-1β) and IL-18. Although initially the inflammasome was described as a complex that affects infection and inflammation, subsequent evidence has suggested that inflammasome activation influences many metabolic disorders, including atherosclerosis, type 2 diabetes, gout and obesity. Another feature of inflammation in general and the inflammasome specifically is that the activation process has a profound effect on aerobic glycolysis (the 'Warburg effect'). Here we explore how the Warburg effect might be linked to inflammation and inflammasome activation." @default.
• W1593760300 created "2016-06-24" @default.
• W1593760300 creator A5019419731 @default.
• W1593760300 creator A5047650515 @default.
• W1593760300 creator A5086513049 @default.
• W1593760300 date "2012-03-19" @default.
• W1593760300 modified "2023-10-05" @default.
• W1593760300 title "A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?" @default.
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• W1593760300 doi "https://doi.org/10.1038/ni.2228" @default.
• W1593760300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4090390" @default.

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