Matches in SemOpenAlex for { <https://semopenalex.org/work/W1593941582> ?p ?o ?g. }
- W1593941582 endingPage "172" @default.
- W1593941582 startingPage "159" @default.
- W1593941582 abstract "The lining of the gastrointestinal tract is our largest external surface. This surface performs a difficult task; it needs to be in immediate contact with the contents of the intestine such that nutrients are efficiently absorbed, and it needs to protect against the intrusion of harmful entities, such as toxins and bacteria that may enter the digestive system with food. Thus, the state of the gut needs to be monitored, and the gut itself needs to react to its contents. Signalling is through the immune system, endocrine hormones, and the nervous system. It is therefore no surprise that the digestive tract has three control systems that are more extensive than those of any other organ: the gut immune system, in which 70% of the body's immune cells are found; the gastroenteropancreatic endocrine system, which uses more than 30 identified hormones; and the enteric nervous system, which contains of the order of 10 8 neurons. Thus, the gastrointestinal tract has an integrated response to changes in its lumenal contents. When this response is maladjusted, or is overwhelmed by injurious substances, the consequences can be severe, as in cholera intoxication, or debilitating, as in the irritable bowel syndrome. Thus, it is essential to obtain a full understanding of the manner in which the lumenal content of the gut is sensed, and how the body reacts to the information. This chapter discusses the neurons of the gut, but also includes descriptions of the other major gut signalling systems, the gut immune and gut endocrine systems." @default.
- W1593941582 created "2016-06-24" @default.
- W1593941582 creator A5060226120 @default.
- W1593941582 creator A5083426666 @default.
- W1593941582 date "2000-01-01" @default.
- W1593941582 modified "2023-09-25" @default.
- W1593941582 title "Responses of afferent neurons to the contents of the digestive tract, and their relation to endocrine and immune responses" @default.
- W1593941582 cites W1532026214 @default.
- W1593941582 cites W1614693610 @default.
- W1593941582 cites W1662913097 @default.
- W1593941582 cites W173988102 @default.
- W1593941582 cites W1898760913 @default.
- W1593941582 cites W1968666385 @default.
- W1593941582 cites W1972976241 @default.
- W1593941582 cites W1979133534 @default.
- W1593941582 cites W1985580976 @default.
- W1593941582 cites W1990106485 @default.
- W1593941582 cites W1995842005 @default.
- W1593941582 cites W2002297978 @default.
- W1593941582 cites W2003004073 @default.
- W1593941582 cites W2004460535 @default.
- W1593941582 cites W2005843560 @default.
- W1593941582 cites W2008446663 @default.
- W1593941582 cites W2029364850 @default.
- W1593941582 cites W2030203846 @default.
- W1593941582 cites W2037370594 @default.
- W1593941582 cites W2037826839 @default.
- W1593941582 cites W2039665401 @default.
- W1593941582 cites W2039906907 @default.
- W1593941582 cites W2041439233 @default.
- W1593941582 cites W2048628319 @default.
- W1593941582 cites W2049332256 @default.
- W1593941582 cites W2058278066 @default.
- W1593941582 cites W2063601395 @default.
- W1593941582 cites W2063945815 @default.
- W1593941582 cites W2067095284 @default.
- W1593941582 cites W2067958046 @default.
- W1593941582 cites W2069718130 @default.
- W1593941582 cites W2075540132 @default.
- W1593941582 cites W2075678041 @default.
- W1593941582 cites W2079608193 @default.
- W1593941582 cites W2080442768 @default.
- W1593941582 cites W2100470623 @default.
- W1593941582 cites W2106369348 @default.
- W1593941582 cites W2113650236 @default.
- W1593941582 cites W2130500248 @default.
- W1593941582 cites W2134867426 @default.
- W1593941582 cites W2142465720 @default.
- W1593941582 cites W2159882319 @default.
- W1593941582 cites W2169565924 @default.
- W1593941582 cites W2230572091 @default.
- W1593941582 cites W2314551209 @default.
- W1593941582 cites W2401019107 @default.
- W1593941582 cites W2467338282 @default.
- W1593941582 cites W2617400496 @default.
- W1593941582 cites W4231002230 @default.
- W1593941582 cites W4299893026 @default.
- W1593941582 doi "https://doi.org/10.1016/s0079-6123(08)62136-6" @default.
- W1593941582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10737056" @default.
- W1593941582 hasPublicationYear "2000" @default.
- W1593941582 type Work @default.
- W1593941582 sameAs 1593941582 @default.
- W1593941582 citedByCount "16" @default.
- W1593941582 countsByYear W15939415822015 @default.
- W1593941582 countsByYear W15939415822019 @default.
- W1593941582 countsByYear W15939415822021 @default.
- W1593941582 countsByYear W15939415822022 @default.
- W1593941582 crossrefType "book-chapter" @default.
- W1593941582 hasAuthorship W1593941582A5060226120 @default.
- W1593941582 hasAuthorship W1593941582A5083426666 @default.
- W1593941582 hasConcept C103395026 @default.
- W1593941582 hasConcept C126322002 @default.
- W1593941582 hasConcept C134018914 @default.
- W1593941582 hasConcept C169760540 @default.
- W1593941582 hasConcept C203014093 @default.
- W1593941582 hasConcept C2779263132 @default.
- W1593941582 hasConcept C2992581678 @default.
- W1593941582 hasConcept C42407357 @default.
- W1593941582 hasConcept C46699223 @default.
- W1593941582 hasConcept C71315377 @default.
- W1593941582 hasConcept C71924100 @default.
- W1593941582 hasConcept C86803240 @default.
- W1593941582 hasConcept C8891405 @default.
- W1593941582 hasConceptScore W1593941582C103395026 @default.
- W1593941582 hasConceptScore W1593941582C126322002 @default.
- W1593941582 hasConceptScore W1593941582C134018914 @default.
- W1593941582 hasConceptScore W1593941582C169760540 @default.
- W1593941582 hasConceptScore W1593941582C203014093 @default.
- W1593941582 hasConceptScore W1593941582C2779263132 @default.
- W1593941582 hasConceptScore W1593941582C2992581678 @default.
- W1593941582 hasConceptScore W1593941582C42407357 @default.
- W1593941582 hasConceptScore W1593941582C46699223 @default.
- W1593941582 hasConceptScore W1593941582C71315377 @default.
- W1593941582 hasConceptScore W1593941582C71924100 @default.
- W1593941582 hasConceptScore W1593941582C86803240 @default.
- W1593941582 hasConceptScore W1593941582C8891405 @default.
- W1593941582 hasLocation W15939415821 @default.
- W1593941582 hasLocation W15939415822 @default.