FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1594067951> ?p ?o ?g. }

• W1594067951 endingPage "11666" @default.
• W1594067951 startingPage "11656" @default.
• W1594067951 abstract "Behavioral studies have established a role for adult-born dentate granule cells in discriminating between similar memories. However, it is unclear how these cells mediate memory discrimination. Excitability is enhanced in maturing adult-born neurons, spurring the hypothesis that the activity of these cells “directly” encodes and stores memories. An alternative hypothesis posits that maturing neurons “indirectly” contribute to memory encoding by regulating excitation–inhibition balance. We evaluated these alternatives by using dentate-sensitive active place avoidance tasks to assess experience-dependent changes in dentate field potentials in the presence and absence of neurogenesis. Before training, X-ray ablation of adult neurogenesis-reduced dentate responses to perforant-path stimulation and shifted EPSP-spike coupling leftward. These differences were unchanged after place avoidance training with the shock zone in the initial location, which both groups learned to avoid equally well. In contrast, sham-treated mice decreased dentate responses and shifted EPSP-spike coupling leftward after the shock zone was relocated, whereas X-irradiated mice failed to show these changes in dentate function and were impaired on this test of memory discrimination. During place avoidance, excitation–inhibition coupled neural synchrony in dentate local field potentials was reduced in X-irradiated mice, especially in the θ band. The difference was most prominent during conflict learning, which is impaired in the X-irradiated mice. These findings indicate that maturing adult-born neurons regulate both functional network plasticity in response to memory discrimination and dentate excitation–inhibition coordination. The most parsimonious interpretation of these results is that adult neurogenesis indirectly regulates hippocampal information processing. <b>SIGNIFICANCE STATEMENT</b> Adult-born neurons in the hippocampal dentate gyrus are important for flexibly using memories, but the mechanism is controversial. Using tests of hippocampus-dependent place avoidance learning and dentate electrophysiology in mice with normal or ablated neurogenesis, we find that maturing adult-born neurons are crucial only when memory must be used flexibly, and that these neurons regulate dentate gyrus synaptic and spiking responses to neocortical input rather than directly storing information, as has been proposed. A day after learning to avoid the initial or changed locations of shock, the dentate synaptic responses are enhanced or suppressed, respectively, unlike mice lacking adult neurogenesis, which did not change. The contribution of adult neurogenesis to memory is indirect, by regulating dentate excitation–inhibition coupling." @default.
• W1594067951 created "2016-06-24" @default.
• W1594067951 creator A5040427737 @default.
• W1594067951 creator A5043384048 @default.
• W1594067951 creator A5077973187 @default.
• W1594067951 creator A5080253300 @default.
• W1594067951 creator A5082256940 @default.
• W1594067951 date "2015-08-19" @default.
• W1594067951 modified "2023-10-17" @default.
• W1594067951 title "Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells" @default.
• W1594067951 cites W1579526015 @default.
• W1594067951 cites W1956591954 @default.
• W1594067951 cites W1977999774 @default.
• W1594067951 cites W1980576528 @default.
• W1594067951 cites W1981917260 @default.
• W1594067951 cites W1982175565 @default.
• W1594067951 cites W1986428552 @default.
• W1594067951 cites W1989693594 @default.
• W1594067951 cites W1996874802 @default.
• W1594067951 cites W2000520243 @default.
• W1594067951 cites W2001550558 @default.
• W1594067951 cites W2003237927 @default.
• W1594067951 cites W2003520218 @default.
• W1594067951 cites W2008085800 @default.
• W1594067951 cites W2010053974 @default.
• W1594067951 cites W2011230199 @default.
• W1594067951 cites W2014460069 @default.
• W1594067951 cites W2015775161 @default.
• W1594067951 cites W2016800141 @default.
• W1594067951 cites W2018934769 @default.
• W1594067951 cites W2020782768 @default.
• W1594067951 cites W2023147143 @default.
• W1594067951 cites W2023343492 @default.
• W1594067951 cites W2028889739 @default.
• W1594067951 cites W2047057213 @default.
• W1594067951 cites W2047925020 @default.
• W1594067951 cites W2050305231 @default.
• W1594067951 cites W2051150606 @default.
• W1594067951 cites W2056091956 @default.
• W1594067951 cites W2060589548 @default.
• W1594067951 cites W2061890549 @default.
• W1594067951 cites W2061960110 @default.
• W1594067951 cites W2063466545 @default.
• W1594067951 cites W2065754676 @default.
• W1594067951 cites W2069785065 @default.
• W1594067951 cites W2085974955 @default.
• W1594067951 cites W2089059900 @default.
• W1594067951 cites W2092245844 @default.
• W1594067951 cites W2094793842 @default.
• W1594067951 cites W2095484045 @default.
• W1594067951 cites W2099751838 @default.
• W1594067951 cites W2109301660 @default.
• W1594067951 cites W2114501218 @default.
• W1594067951 cites W2118454691 @default.
• W1594067951 cites W2119051448 @default.
• W1594067951 cites W2119060662 @default.
• W1594067951 cites W2120485135 @default.
• W1594067951 cites W2122196422 @default.
• W1594067951 cites W2125095601 @default.
• W1594067951 cites W2131414754 @default.
• W1594067951 cites W2131693039 @default.
• W1594067951 cites W2135046848 @default.
• W1594067951 cites W2139465230 @default.
• W1594067951 cites W2146316688 @default.
• W1594067951 cites W2146816413 @default.
• W1594067951 cites W2148239264 @default.
• W1594067951 cites W2148727841 @default.
• W1594067951 cites W2155032464 @default.
• W1594067951 cites W2200741714 @default.
• W1594067951 cites W2416079629 @default.
• W1594067951 doi "https://doi.org/10.1523/jneurosci.0885-15.2015" @default.
• W1594067951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4540800" @default.
• W1594067951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26290242" @default.
• W1594067951 hasPublicationYear "2015" @default.
• W1594067951 type Work @default.
• W1594067951 sameAs 1594067951 @default.
• W1594067951 citedByCount "63" @default.
• W1594067951 countsByYear W15940679512016 @default.
• W1594067951 countsByYear W15940679512017 @default.
• W1594067951 countsByYear W15940679512018 @default.
• W1594067951 countsByYear W15940679512019 @default.
• W1594067951 countsByYear W15940679512020 @default.
• W1594067951 countsByYear W15940679512021 @default.
• W1594067951 countsByYear W15940679512022 @default.
• W1594067951 countsByYear W15940679512023 @default.
• W1594067951 crossrefType "journal-article" @default.
• W1594067951 hasAuthorship W1594067951A5040427737 @default.
• W1594067951 hasAuthorship W1594067951A5043384048 @default.
• W1594067951 hasAuthorship W1594067951A5077973187 @default.
• W1594067951 hasAuthorship W1594067951A5080253300 @default.
• W1594067951 hasAuthorship W1594067951A5082256940 @default.
• W1594067951 hasBestOaLocation W15940679511 @default.
• W1594067951 hasConcept C112592302 @default.
• W1594067951 hasConcept C148762608 @default.
• W1594067951 hasConcept C15744967 @default.
• W1594067951 hasConcept C169760540 @default.
• W1594067951 hasConcept C170493617 @default.
• W1594067951 hasConcept C17077164 @default.

• next