FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1594098557> ?p ?o ?g. }

• W1594098557 abstract "Embryonic stem cells (ESCs) are pluripotent cells capable of both limitless selfrenewal and differentiation into all embryonic lineages, and thus ESCs can give rise to any adult cell type. When ESCs are stably maintained in culture and their pluripotency is strictly enforced, they can serve as an unlimited source for tissue replacement in regenerative medicine for degenerative diseases such as neural disorders, heart disease, and type I diabetes. They also offer enormous potential for drug discovery and toxicology, human developmental biology, and cancer research. Studies of human ESCs (hESCs) biology have developed rapidly since the first reports of their derivation in 1998 (Thomson et al., 1998). Many studies have tried to manipulate the growth and differentiation conditions of hESCs with variable success (Biswas and Hutchins, 2007; Hoffman and Carpenter, 2005). hESCs have been differentiated into the derivatives of all three germ layers: ectoderm, mesoderm, and endoderm. Specifically, these derivatives include cardiomyocytes, neural cells, hepatocyte-like cells, endothelial cells, pancreatic hormone expressing endocrine cells, and hematopoietic progenitor cells (Barberi et al., 2007; Carpenter et al., 2003; D'Amour et al., 2006; Levenberg et al., 2007; Lu et al., 2007; Roy et al., 2006; Wang et al., 2007), and thus hESCs have great potential for use in regenerative medicine to restore heart disease, neuronal functions, hepatic disease, blood vessels, and type I diabetes. In addition, mouse ESCs (mESCs) can generate hepatocytes (Gouon-Evans et al., 2006; Soto-Gutierrez et al., 2007), insulinproducing cells (Schroeder et al., 2006), cerebellar neurons (Salero and Hatten, 2007), and even germ cells (West et al., 2006) in vitro, suggesting that hESC can be applied much more widely to regenerative medicine in the future. On October 2010, Geron corporation in United States announced plans to initiate the phase I clinical trial of hESC-derived oligodendrocyte progenitor cells. However, the clinical application of hESCs is restricted thus far for alleged ethical and scientific reasons. First, hESC research often faces opposition from those who object to the destruction of human embryos. Second, ESC therapy potentially poses the risk of tumorigenesis. ESCs frequently form teratocarcinomas when transplanted into mice. Moreover, the ability of ESCs to provide differentiated cells for regenerative medicine will require continual maintenance of the undifferentiated stem cells for long periods in culture. However, chromosomal stability during extended cell passage cannot be guaranteed, and recent cytogenetic studies of ESCs have revealed karyotypic aberrations (Baker et al., 2007). Third, cell replacement therapies have been limited by the availability of sufficient quantities of cells for transplantation. Although there are many reports describing a method to maintain ESC properties in culture, the large-scale culture of" @default.
• W1594098557 created "2016-06-24" @default.
• W1594098557 creator A5016298609 @default.
• W1594098557 creator A5027421629 @default.
• W1594098557 creator A5063243033 @default.
• W1594098557 date "2011-04-26" @default.
• W1594098557 modified "2023-10-03" @default.
• W1594098557 title "Molecular Biomarkers of Embryonic Stem Cells" @default.
• W1594098557 cites W1513329088 @default.
• W1594098557 cites W1600166721 @default.
• W1594098557 cites W1608762409 @default.
• W1594098557 cites W1683423048 @default.
• W1594098557 cites W1750475935 @default.
• W1594098557 cites W1965411245 @default.
• W1594098557 cites W1965428318 @default.
• W1594098557 cites W1966504370 @default.
• W1594098557 cites W1966758700 @default.
• W1594098557 cites W1974365957 @default.
• W1594098557 cites W1974954301 @default.
• W1594098557 cites W1975163937 @default.
• W1594098557 cites W1975665323 @default.
• W1594098557 cites W1979981202 @default.
• W1594098557 cites W1980147031 @default.
• W1594098557 cites W1981088384 @default.
• W1594098557 cites W1987983547 @default.
• W1594098557 cites W1990242832 @default.
• W1594098557 cites W1991707124 @default.
• W1594098557 cites W1996659151 @default.
• W1594098557 cites W1998092663 @default.
• W1594098557 cites W2004211510 @default.
• W1594098557 cites W2006562250 @default.
• W1594098557 cites W2008635881 @default.
• W1594098557 cites W2010031978 @default.
• W1594098557 cites W2010765881 @default.
• W1594098557 cites W2012189328 @default.
• W1594098557 cites W2013035180 @default.
• W1594098557 cites W2013297672 @default.
• W1594098557 cites W2015396326 @default.
• W1594098557 cites W2017246093 @default.
• W1594098557 cites W2017438799 @default.
• W1594098557 cites W2020012816 @default.
• W1594098557 cites W2023168515 @default.
• W1594098557 cites W2026299035 @default.
• W1594098557 cites W2026834597 @default.
• W1594098557 cites W2038596854 @default.
• W1594098557 cites W2039551265 @default.
• W1594098557 cites W2043126651 @default.
• W1594098557 cites W2048295632 @default.
• W1594098557 cites W2053860318 @default.
• W1594098557 cites W2053911973 @default.
• W1594098557 cites W2054361177 @default.
• W1594098557 cites W2058485556 @default.
• W1594098557 cites W2063569176 @default.
• W1594098557 cites W2069249593 @default.
• W1594098557 cites W2070815461 @default.
• W1594098557 cites W2078918257 @default.
• W1594098557 cites W2081825152 @default.
• W1594098557 cites W2082365549 @default.
• W1594098557 cites W2082496903 @default.
• W1594098557 cites W2084869091 @default.
• W1594098557 cites W2085171607 @default.
• W1594098557 cites W2086943348 @default.
• W1594098557 cites W2088128367 @default.
• W1594098557 cites W2088861927 @default.
• W1594098557 cites W2089585045 @default.
• W1594098557 cites W2090260381 @default.
• W1594098557 cites W2091790925 @default.
• W1594098557 cites W2098717020 @default.
• W1594098557 cites W2104708641 @default.
• W1594098557 cites W2105299356 @default.
• W1594098557 cites W2107575419 @default.
• W1594098557 cites W2110015307 @default.
• W1594098557 cites W2110702717 @default.
• W1594098557 cites W2118290853 @default.
• W1594098557 cites W2118922078 @default.
• W1594098557 cites W2120060713 @default.
• W1594098557 cites W2125987139 @default.
• W1594098557 cites W2126851387 @default.
• W1594098557 cites W2128786355 @default.
• W1594098557 cites W2138977668 @default.
• W1594098557 cites W2142046859 @default.
• W1594098557 cites W2142482111 @default.
• W1594098557 cites W2147015050 @default.
• W1594098557 cites W2154712506 @default.
• W1594098557 cites W2158048826 @default.
• W1594098557 cites W2164555290 @default.
• W1594098557 cites W2165135585 @default.
• W1594098557 cites W2169529166 @default.
• W1594098557 cites W2171481975 @default.
• W1594098557 cites W2317449572 @default.
• W1594098557 cites W233481338 @default.
• W1594098557 cites W3021303491 @default.
• W1594098557 doi "https://doi.org/10.5772/14631" @default.
• W1594098557 hasPublicationYear "2011" @default.
• W1594098557 type Work @default.
• W1594098557 sameAs 1594098557 @default.
• W1594098557 citedByCount "0" @default.
• W1594098557 crossrefType "book-chapter" @default.
• W1594098557 hasAuthorship W1594098557A5016298609 @default.
• W1594098557 hasAuthorship W1594098557A5027421629 @default.

• next