Matches in SemOpenAlex for { <https://semopenalex.org/work/W1594212912> ?p ?o ?g. }
- W1594212912 endingPage "914" @default.
- W1594212912 startingPage "903" @default.
- W1594212912 abstract "Abstract The pathogenesis of Shigella flexneri infection centers on the ability of this organism to invade epithelial cells and initiate an intense inflammatory reaction. Because NF-κB is an important transcriptional regulator of genes involved in inflammation, we investigated the role of this transcription factor during S. flexneri infection of epithelial cells. Infection of HeLa cells with invasive S. flexneri induced NF-κB DNA-binding activity; noninvasive S. flexneri strains did not lead to this activation. The pathway leading to NF-κB activation by invasive S. flexneri involved the kinases, NF-κB-inducing kinase, IκB kinase-1, and IκB kinase-2. NF-κB activation was linked to inflammation, because invasive S. flexneri activated an IL-8 promoter-driven reporter gene, and the κB site within this promoter was indispensable for its induction. Microinjection of bacterial culture supernatants into HeLa cells suggested that LPS is responsible for NF-κB activation by S. flexneri infection. In conclusion, the eukaryotic transcription factor NF-κB was activated during S. flexneri infection of epithelial cells, which suggests a role for this transcriptional regulator in modulating the immune response during infection in vivo." @default.
- W1594212912 created "2016-06-24" @default.
- W1594212912 creator A5004244093 @default.
- W1594212912 creator A5049396535 @default.
- W1594212912 creator A5069666784 @default.
- W1594212912 creator A5070424975 @default.
- W1594212912 date "2000-07-15" @default.
- W1594212912 modified "2023-10-06" @default.
- W1594212912 title "Invasive<i>Shigella flexneri</i>Activates NF-κB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells" @default.
- W1594212912 cites W148231546 @default.
- W1594212912 cites W1488327245 @default.
- W1594212912 cites W1503383048 @default.
- W1594212912 cites W1538577248 @default.
- W1594212912 cites W1589541158 @default.
- W1594212912 cites W1636221253 @default.
- W1594212912 cites W1640670825 @default.
- W1594212912 cites W1653610611 @default.
- W1594212912 cites W1661180389 @default.
- W1594212912 cites W1710793119 @default.
- W1594212912 cites W1829553626 @default.
- W1594212912 cites W1841963910 @default.
- W1594212912 cites W1846272158 @default.
- W1594212912 cites W1856169132 @default.
- W1594212912 cites W1874605356 @default.
- W1594212912 cites W1921336451 @default.
- W1594212912 cites W1922098314 @default.
- W1594212912 cites W1965849096 @default.
- W1594212912 cites W1968061454 @default.
- W1594212912 cites W1979520552 @default.
- W1594212912 cites W1980768491 @default.
- W1594212912 cites W1988282769 @default.
- W1594212912 cites W1989844987 @default.
- W1594212912 cites W1994888948 @default.
- W1594212912 cites W2003479854 @default.
- W1594212912 cites W2006660114 @default.
- W1594212912 cites W2021418970 @default.
- W1594212912 cites W2022013606 @default.
- W1594212912 cites W2028644250 @default.
- W1594212912 cites W2036770241 @default.
- W1594212912 cites W2045326445 @default.
- W1594212912 cites W2045888747 @default.
- W1594212912 cites W2047376205 @default.
- W1594212912 cites W2051831012 @default.
- W1594212912 cites W2053111401 @default.
- W1594212912 cites W2067680656 @default.
- W1594212912 cites W2070853191 @default.
- W1594212912 cites W2079968415 @default.
- W1594212912 cites W2084708403 @default.
- W1594212912 cites W2086894122 @default.
- W1594212912 cites W2087596041 @default.
- W1594212912 cites W2091073005 @default.
- W1594212912 cites W2093098202 @default.
- W1594212912 cites W2099144632 @default.
- W1594212912 cites W2101257770 @default.
- W1594212912 cites W2101804849 @default.
- W1594212912 cites W2102552341 @default.
- W1594212912 cites W2104583512 @default.
- W1594212912 cites W2106877484 @default.
- W1594212912 cites W2110210117 @default.
- W1594212912 cites W2112135370 @default.
- W1594212912 cites W2112552808 @default.
- W1594212912 cites W2126941629 @default.
- W1594212912 cites W2142277736 @default.
- W1594212912 cites W2142790535 @default.
- W1594212912 cites W2145078103 @default.
- W1594212912 cites W2146817146 @default.
- W1594212912 cites W2149307202 @default.
- W1594212912 cites W2153324964 @default.
- W1594212912 cites W2155933617 @default.
- W1594212912 cites W2157086104 @default.
- W1594212912 cites W2159979956 @default.
- W1594212912 cites W2160906312 @default.
- W1594212912 cites W2161767156 @default.
- W1594212912 cites W2202855866 @default.
- W1594212912 cites W2728081960 @default.
- W1594212912 cites W4313335805 @default.
- W1594212912 doi "https://doi.org/10.4049/jimmunol.165.2.903" @default.
- W1594212912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10878365" @default.
- W1594212912 hasPublicationYear "2000" @default.
- W1594212912 type Work @default.
- W1594212912 sameAs 1594212912 @default.
- W1594212912 citedByCount "242" @default.
- W1594212912 countsByYear W15942129122012 @default.
- W1594212912 countsByYear W15942129122013 @default.
- W1594212912 countsByYear W15942129122014 @default.
- W1594212912 countsByYear W15942129122015 @default.
- W1594212912 countsByYear W15942129122016 @default.
- W1594212912 countsByYear W15942129122017 @default.
- W1594212912 countsByYear W15942129122018 @default.
- W1594212912 countsByYear W15942129122019 @default.
- W1594212912 countsByYear W15942129122020 @default.
- W1594212912 countsByYear W15942129122021 @default.
- W1594212912 countsByYear W15942129122022 @default.
- W1594212912 countsByYear W15942129122023 @default.
- W1594212912 crossrefType "journal-article" @default.
- W1594212912 hasAuthorship W1594212912A5004244093 @default.
- W1594212912 hasAuthorship W1594212912A5049396535 @default.
- W1594212912 hasAuthorship W1594212912A5069666784 @default.