FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1594236859> ?p ?o ?g. }

• W1594236859 endingPage "6556" @default.
• W1594236859 startingPage "6546" @default.
• W1594236859 abstract "The genetic analysis of larval neuromuscular junctions (NMJs) of Drosophila has provided detailed insights into molecular mechanisms that control the morphological and physiological development of these glutamatergic synapses. However, because of the chronic defects caused by mutations, a time-resolved analysis of these mechanisms and their functional relationships has been difficult so far. In this study we provide a first temporal map of some of the molecular and cellular key processes, which are triggered in wild-type animals by natural larval locomotor activity and then mediate experience-dependent strengthening of larval NMJs. Larval locomotor activity was increased either by chronically rearing a larval culture at 29 degrees C instead of 18 or 25 degrees C or by acutely transferring larvae from a culture vial onto agar plates. Within 2 hr of enhanced locomotor activity, NMJs showed a significant potentiation of signal transmission that was rapidly reversed by an induced paralysis of the temperature-sensitive mutant parats1. Enhanced locomotor activity was also associated with a significant increase in the number of large subsynaptic translation aggregates. After 4 hr, postsynaptic DGluR-IIA glutamate receptor subunits started to transiently accumulate in ring-shaped areas around synapses, and they condensed later on, after chronic locomotor stimulation at 29 degrees C, into typical postsynaptic patches. These NMJs showed a reduced perisynaptic expression of the cell adhesion molecule Fasciclin II, an increased number of junctional boutons, and significantly more active zones. Such temporal mapping of experience-dependent adaptations at developing wild-type and mutant NMJs will provide detailed insights into the dynamic control of glutamatergic signal transmission." @default.
• W1594236859 created "2016-06-24" @default.
• W1594236859 creator A5003046646 @default.
• W1594236859 creator A5021158455 @default.
• W1594236859 creator A5047265098 @default.
• W1594236859 creator A5054234383 @default.
• W1594236859 creator A5088765429 @default.
• W1594236859 date "2003-07-23" @default.
• W1594236859 modified "2023-10-16" @default.
• W1594236859 title "Experience-Dependent Strengthening of<i>Drosophila</i>Neuromuscular Junctions" @default.
• W1594236859 cites W100014517 @default.
• W1594236859 cites W1510879979 @default.
• W1594236859 cites W1524360401 @default.
• W1594236859 cites W1590006710 @default.
• W1594236859 cites W1614445885 @default.
• W1594236859 cites W1635044580 @default.
• W1594236859 cites W1647105274 @default.
• W1594236859 cites W1650765334 @default.
• W1594236859 cites W1662316193 @default.
• W1594236859 cites W1807443753 @default.
• W1594236859 cites W1808236879 @default.
• W1594236859 cites W1880998152 @default.
• W1594236859 cites W1898153757 @default.
• W1594236859 cites W1941436081 @default.
• W1594236859 cites W1955231649 @default.
• W1594236859 cites W1962484858 @default.
• W1594236859 cites W1965202553 @default.
• W1594236859 cites W1965721018 @default.
• W1594236859 cites W1966085915 @default.
• W1594236859 cites W1972071614 @default.
• W1594236859 cites W1972461292 @default.
• W1594236859 cites W1972529694 @default.
• W1594236859 cites W1973707586 @default.
• W1594236859 cites W1974753375 @default.
• W1594236859 cites W1979026763 @default.
• W1594236859 cites W1982026643 @default.
• W1594236859 cites W1995843413 @default.
• W1594236859 cites W1997955557 @default.
• W1594236859 cites W2003821601 @default.
• W1594236859 cites W2006305827 @default.
• W1594236859 cites W2010131716 @default.
• W1594236859 cites W2014716943 @default.
• W1594236859 cites W2040687574 @default.
• W1594236859 cites W2040949304 @default.
• W1594236859 cites W2042604124 @default.
• W1594236859 cites W2043867460 @default.
• W1594236859 cites W2044594834 @default.
• W1594236859 cites W2046511552 @default.
• W1594236859 cites W2048443355 @default.
• W1594236859 cites W2048743675 @default.
• W1594236859 cites W2052600995 @default.
• W1594236859 cites W2056422983 @default.
• W1594236859 cites W2063832663 @default.
• W1594236859 cites W2065178022 @default.
• W1594236859 cites W2069382449 @default.
• W1594236859 cites W2079064394 @default.
• W1594236859 cites W2080778713 @default.
• W1594236859 cites W2081555538 @default.
• W1594236859 cites W2085270288 @default.
• W1594236859 cites W2093403258 @default.
• W1594236859 cites W2094975095 @default.
• W1594236859 cites W2106349285 @default.
• W1594236859 cites W2106417817 @default.
• W1594236859 cites W2110711096 @default.
• W1594236859 cites W2115391765 @default.
• W1594236859 cites W2126465155 @default.
• W1594236859 cites W2141588318 @default.
• W1594236859 cites W2289056722 @default.
• W1594236859 cites W2395373942 @default.
• W1594236859 cites W2410996109 @default.
• W1594236859 cites W4296759712 @default.
• W1594236859 cites W4297686617 @default.
• W1594236859 doi "https://doi.org/10.1523/jneurosci.23-16-06546.2003" @default.
• W1594236859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6740647" @default.
• W1594236859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12878696" @default.
• W1594236859 hasPublicationYear "2003" @default.
• W1594236859 type Work @default.
• W1594236859 sameAs 1594236859 @default.
• W1594236859 citedByCount "184" @default.
• W1594236859 countsByYear W15942368592012 @default.
• W1594236859 countsByYear W15942368592013 @default.
• W1594236859 countsByYear W15942368592014 @default.
• W1594236859 countsByYear W15942368592015 @default.
• W1594236859 countsByYear W15942368592016 @default.
• W1594236859 countsByYear W15942368592017 @default.
• W1594236859 countsByYear W15942368592018 @default.
• W1594236859 countsByYear W15942368592019 @default.
• W1594236859 countsByYear W15942368592020 @default.
• W1594236859 countsByYear W15942368592021 @default.
• W1594236859 countsByYear W15942368592022 @default.
• W1594236859 countsByYear W15942368592023 @default.
• W1594236859 crossrefType "journal-article" @default.
• W1594236859 hasAuthorship W1594236859A5003046646 @default.
• W1594236859 hasAuthorship W1594236859A5021158455 @default.
• W1594236859 hasAuthorship W1594236859A5047265098 @default.
• W1594236859 hasAuthorship W1594236859A5054234383 @default.
• W1594236859 hasAuthorship W1594236859A5088765429 @default.
• W1594236859 hasBestOaLocation W15942368591 @default.

• next