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• W1594289602 abstract "Developing a quantifiable in vitro model of steatosis is critical in understanding the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and searchingfor effective therapies. Using an ORO-based colorimetric measurement, we developed a convenient assay to qualify the degree of OA-induced steatosis in HepG2 cells. We demonstrated that in the absence of exogenous inflammatory mediators, OA-induced steatosis was associated with increased production and secretion of tumor necrosis factor alpha and decreased expression of peroxisome proliferators-activated receptor alpha in HepG2 cells. OA-induced steatosis was also associated with increased lipid peroxidation, apoptosis, but decreased proliferation in these cells. The increased lipid peroxidation was related to decreased SOD-1, a free radical scavenger enzyme; while increased apoptosis was related to increased active caspase-9. The decreased proliferation mediated by OA-induced steatosis was associated with increased production of p27 with unchanged alanine transaminase (ALT) level in the culture medium, indicating OA-induced steatosis alters cell cycle progression without direct toxicity to these cells. In conclusion, the present study developed a colorimetric assay that accurately quantifies OA-induced steatosis in HepG2 cells. In the absence of exogenous inflammatory mediators, OA-induced steatosis results in a series of pathophysilogical changes in HepG2 cells, indicating direct pathogenic roles of hepatocytes in NAFLD." @default.
• W1594289602 created "2016-06-24" @default.
• W1594289602 creator A5003875568 @default.
• W1594289602 creator A5034043954 @default.
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• W1594289602 date "2010-01-01" @default.
• W1594289602 modified "2023-10-18" @default.
• W1594289602 title "Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells." @default.
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• W1594289602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2826826" @default.
• W1594289602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20182586" @default.
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