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- W1594489623 abstract "The chapter discusses a study on epithelial sodium channels in cystic fibrosis (CF). The chapter describes a discussion on the mechanisms that could account for the observations made in the experimental systems, and their relevance to transport of Na+ in normal and the CF airway epithelia. The chapter includes a summary of findings of different investigators studying the cystic fibrosis transmembrane conductance regulator (CFTR)-induced inhibition of epithelial sodium channels (ENaCs) in different cell expression systems. CF is an example of the ways in which the understanding of one illness can benefit from the knowledge gained in studies of other diseases. Although many questions about the pathogenesis of CF are yet to be answered, the new knowledge of the mechanism of Na+ transport in general and in the pathophysiology of human genetic hypertension and pseudohypoaldostronism, perceived because cloning of ENaCs will help to understand the mechanism of Na+ hyperabsorption in CF airways, and vice versa. The first, and essentially the most unequivocal, evidence for involvement of amiloride-sensitive Na+ channels in the pathogenesis of mucoviscidosis came from direct measurements of transepithelial electric potential difference (PD) in both upper and lower airways, and in the microperfused ducts of sweat glands of the patients affected with this disease." @default.
- W1594489623 created "2016-06-24" @default.
- W1594489623 creator A5023640581 @default.
- W1594489623 creator A5048753485 @default.
- W1594489623 date "1999-01-01" @default.
- W1594489623 modified "2023-09-26" @default.
- W1594489623 title "Chapter 20 Epithelial Sodium Channels in Cystic Fibrosis" @default.
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