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- W1594500521 abstract "With the aid of a specific GC-MS method utilizing negative ion-chemical ionization, the extracellular and intracellular concentrations of the free 2-thiouracils, 2-thiouracil and 6-propyl-2-thiouracil were measured after their incubation with melanotic and amelanotic melanocytes.Only with the melanotic cell preparation exposed to low concentrations of thiouracil (40 ng/106 cells) was there a reduction of the thiouracil concentration. When the extracellular 2-thiouracil concentration was increased a thousandfold (40 μg/106 cells), appreciable accumulation by the melanotic melanocytes was observed only with the more lipophilic 2-thiouracil, propylthiouracil, which also paralleled its greater toxicity compared with thiouracil. Both these observations suggest increased propylthiouracil cell penetration compared with thiouracil due to its greater lipophilicity." @default.
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- W1594500521 date "1995-09-01" @default.
- W1594500521 modified "2023-09-27" @default.
- W1594500521 title "Accumulation of 2‐Thiouracils by Melanotic Melanocytes" @default.
- W1594500521 doi "https://doi.org/10.1111/j.2042-7158.1995.tb00462.x" @default.
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