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- W1594501889 abstract "Several therapeutic antibodies are available for the treatment of chronic plaque type psoriasis. Ustekinumab (a monoclonal IL12/23 antagonist) is one of these antibodies (1) and it is currently being investigated for other indications. For adalimumab (a monoclonal tumour necrosis factor α antagonist) a positive correlation has been observed between adalimumab trough levels and clinical efficacy, both showing a negative correlation with anti-drug antibodies (ADA) to adalimumab (present in 49% of patients) (2). In rheumatoid arthritis, a therapeutic range for adalimumab trough level has been established, which can eventually lead to a more personalised way of administering adalimumab (3). This article is protected by copyright. All rights reserved" @default.
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- W1594501889 date "2015-08-02" @default.
- W1594501889 modified "2023-10-04" @default.
- W1594501889 title "The correlation of clinical efficacy, serum trough levels and antidrug antibodies in ustekinumab-treated patients with psoriasis in a clinical-practice setting" @default.
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- W1594501889 doi "https://doi.org/10.1111/bjd.13834" @default.
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