Matches in SemOpenAlex for { <https://semopenalex.org/work/W1594552382> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1594552382 endingPage "11329" @default.
- W1594552382 startingPage "11323" @default.
- W1594552382 abstract "Using small angle x-ray scattering from solutions of yeast phosphoglycerate kinase, we have measured the radius of gyration of the enzyme both in the presence and in the abscence of ligands. We find that the radius of gyration decreases by 1.09 +/- 0.34 A upon binding both substrates MgATP and 3-phosphoglycerate to form the ternary complex. Smaller decreases, at the limit of the precision of the measurement, were found for the separate binding of MgATP (0.30 +/- 0.50 A). Using computer modeling, it has been estimated that a substrate-induced cleft closure in phosphoglycerate kinase resulting from one lobe rotating 8-14 degrees relative to the other lobe lobe is consistent with this observed change in radius of gyration. We suggest, therefore, that the conformational change that results in the smaller radius of gyration for the ternary complex is a hinge motion of the two lobes which produces a closing of the cleft between the two lobes. The apparent similarity of the ligand-induced change in phosphoglycerate kinase to the cleft closure in hexokinase suggests that this kind of conformational change may prove to be a rather general kinase phenomenon (Bennett, W.S., and Steitz T.A. (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 4848-4852; Anderson, C.M., Zucker, F.H., and Steitz, T.A. (1979) Science 204, 375-380)." @default.
- W1594552382 created "2016-06-24" @default.
- W1594552382 creator A5002753770 @default.
- W1594552382 creator A5005980770 @default.
- W1594552382 creator A5072431891 @default.
- W1594552382 creator A5081248562 @default.
- W1594552382 date "1979-11-01" @default.
- W1594552382 modified "2023-10-09" @default.
- W1594552382 title "Substrate binding closes the cleft between the domains of yeast phosphoglycerate kinase." @default.
- W1594552382 cites W1483067155 @default.
- W1594552382 cites W1527272231 @default.
- W1594552382 cites W1549022509 @default.
- W1594552382 cites W1567953681 @default.
- W1594552382 cites W1574735125 @default.
- W1594552382 cites W1976491443 @default.
- W1594552382 cites W1996537553 @default.
- W1594552382 cites W1997472565 @default.
- W1594552382 cites W2012924146 @default.
- W1594552382 cites W2016000929 @default.
- W1594552382 cites W2041659515 @default.
- W1594552382 cites W2042108994 @default.
- W1594552382 cites W2043147330 @default.
- W1594552382 cites W2048947819 @default.
- W1594552382 cites W2050565744 @default.
- W1594552382 cites W2055100088 @default.
- W1594552382 cites W2066606020 @default.
- W1594552382 cites W2089147203 @default.
- W1594552382 cites W2091585311 @default.
- W1594552382 cites W2120593135 @default.
- W1594552382 cites W2278586565 @default.
- W1594552382 cites W2332798649 @default.
- W1594552382 cites W2607732975 @default.
- W1594552382 doi "https://doi.org/10.1016/s0021-9258(19)86488-8" @default.
- W1594552382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/387770" @default.
- W1594552382 hasPublicationYear "1979" @default.
- W1594552382 type Work @default.
- W1594552382 sameAs 1594552382 @default.
- W1594552382 citedByCount "161" @default.
- W1594552382 countsByYear W15945523822012 @default.
- W1594552382 countsByYear W15945523822013 @default.
- W1594552382 countsByYear W15945523822014 @default.
- W1594552382 countsByYear W15945523822018 @default.
- W1594552382 countsByYear W15945523822019 @default.
- W1594552382 countsByYear W15945523822023 @default.
- W1594552382 crossrefType "journal-article" @default.
- W1594552382 hasAuthorship W1594552382A5002753770 @default.
- W1594552382 hasAuthorship W1594552382A5005980770 @default.
- W1594552382 hasAuthorship W1594552382A5072431891 @default.
- W1594552382 hasAuthorship W1594552382A5081248562 @default.
- W1594552382 hasBestOaLocation W15945523821 @default.
- W1594552382 hasConcept C12554922 @default.
- W1594552382 hasConcept C155911427 @default.
- W1594552382 hasConcept C181199279 @default.
- W1594552382 hasConcept C184235292 @default.
- W1594552382 hasConcept C185592680 @default.
- W1594552382 hasConcept C18903297 @default.
- W1594552382 hasConcept C2777289219 @default.
- W1594552382 hasConcept C2779222958 @default.
- W1594552382 hasConcept C2994592520 @default.
- W1594552382 hasConcept C55493867 @default.
- W1594552382 hasConcept C86803240 @default.
- W1594552382 hasConcept C95444343 @default.
- W1594552382 hasConceptScore W1594552382C12554922 @default.
- W1594552382 hasConceptScore W1594552382C155911427 @default.
- W1594552382 hasConceptScore W1594552382C181199279 @default.
- W1594552382 hasConceptScore W1594552382C184235292 @default.
- W1594552382 hasConceptScore W1594552382C185592680 @default.
- W1594552382 hasConceptScore W1594552382C18903297 @default.
- W1594552382 hasConceptScore W1594552382C2777289219 @default.
- W1594552382 hasConceptScore W1594552382C2779222958 @default.
- W1594552382 hasConceptScore W1594552382C2994592520 @default.
- W1594552382 hasConceptScore W1594552382C55493867 @default.
- W1594552382 hasConceptScore W1594552382C86803240 @default.
- W1594552382 hasConceptScore W1594552382C95444343 @default.
- W1594552382 hasIssue "22" @default.
- W1594552382 hasLocation W15945523821 @default.
- W1594552382 hasOpenAccess W1594552382 @default.
- W1594552382 hasPrimaryLocation W15945523821 @default.
- W1594552382 hasRelatedWork W1981911623 @default.
- W1594552382 hasRelatedWork W2103837357 @default.
- W1594552382 hasRelatedWork W2117340465 @default.
- W1594552382 hasRelatedWork W2155158959 @default.
- W1594552382 hasRelatedWork W2410001721 @default.
- W1594552382 hasRelatedWork W2417051222 @default.
- W1594552382 hasRelatedWork W2587733587 @default.
- W1594552382 hasRelatedWork W305539055 @default.
- W1594552382 hasRelatedWork W976462640 @default.
- W1594552382 hasRelatedWork W2046536786 @default.
- W1594552382 hasVolume "254" @default.
- W1594552382 isParatext "false" @default.
- W1594552382 isRetracted "false" @default.
- W1594552382 magId "1594552382" @default.
- W1594552382 workType "article" @default.