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• W1594566813 abstract "The in vivo and in vitro metabolism of 3H-testosterone by rat epididymis and the changes in epididymal weight have been studied after castration and treatment with anti-androgens. The utilization of 3H-testosterone was greatly reduced after castration as was the formation of 5α-reduced 17β-hydroxy metabolites. The formation of the 17 -keto metabolites was unaffected. Castration had no effect on the ratio between water and ether soluble radioactivity. Administration of testosterone propionate, necessary for giving normal stimulated prostate weight (150 μg/day), restored the metabolism of testosterone to approximately normal values. Estradiol benzoate and progesterone inhibited metabolism of testosterone in vitro and greatly reduced the formation of DHT (17β-hydroxy-5α-androstan-3-one) and 3α-diol (5α-androstane-3α-17β-diol) by experiments both in vivo and in vitro. No effect of cyproterone acetate could be demonstrated on either the in vitro or in vivo metabolism of testosterone. Castration for 14 days reduced the epididymal weight to about 30% of that found in intact animals. Administration of testosterone propionate restored the epididymal weight to about 80% of normal. Estradiol benzoate and cyproterone acetate given to intact rats led to a decrease in the epididymal weight. Progesterone had no such effect. In 14 days castrated rats receiving testosterone propionate all three anti-androgens reduced the weight of the epididymis. In conclusion, our results show that the metabolic conversion of testosterone in epididymis to DHT and 3α-diol is dramatically dependent on the hormonal status of the animal; castration or treatment with anti-androgens causes a reduced formation of the “active” androgens whilst testosterone replacement treatment restores the metabolism of testosterone to normal." @default.
• W1594566813 created "2016-06-24" @default.
• W1594566813 creator A5025545871 @default.
• W1594566813 date "1976-01-01" @default.
• W1594566813 modified "2023-10-13" @default.
• W1594566813 title "Androgen metabolism by rat epididymis" @default.
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• W1594566813 doi "https://doi.org/10.1016/0039-128x(76)90068-4" @default.
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