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- W1594577401 abstract "Background:Cardiac resynchronization therapy (CRT) has been proposed as a treatment for patients with congestive heart failure (CHF) and prolonged QRS durations. Previous studies have predominantly included patients with left bundle-branch block (LBBB). The Multicenter InSync Randomized Clinical Evaluation (MIRACLE) investigators assessed the efficacy of CRT in patients with CHF with QRS durations > 130 ms and found that CRT lead to improvement in several measures of functional capacity and exercise tolerance. Hypothesis:We designed this retrospective study to determine whether patients with CHF who have conduction abnormalities other than LBBB also respond favorably to CRT. Methods:We divided patients enrolled in the MIRACLE trial into three subgroups according to conduction abnormality - LBBB, right bundle-branch block (RBBB), and nonspecific interventricular conduction delay (IVCD) - and compared the response among and within these groups to CRT or no CRT at baseline and 6-months' follow-up. Results:We found 313 patients with LBBB, 43 with RBBB, and 35 with IVCD. When they received CRT, significant improvement was achieved in functional class (p = 0.001) by patients with RBBB, and in quality of life (p = 0.038) by patients with IVCD. Patients in the RBBB and IVCD groups showed improvement in exercise time and peak oxygen consumption after CRT. Most patients with RBBB (82%) also had either left anterior fascicular block or left posterior fascicular block. Conclusions:Patients with CHF with RBBB and IVCD do benefit from CRT. Improvement with CRT in patients with RBBB may be due to concomitant left-sided conduction abnormalities. Further subgroup analyses of other CRT trials are necessary to validate these results." @default.
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- W1594577401 date "2004-12-01" @default.
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- W1594577401 title "Cardiac resynchronization therapy in patients with heart failure and conduction abnormalities other than left bundle-branch block: Analysis of the multicenter insync randomized clinical evaluation (MIRACLE)" @default.
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- W1594577401 doi "https://doi.org/10.1002/clc.4960271204" @default.
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