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- W1594773485 abstract "We examined sensorimotor brain activity associated with voluntary movements in preschool children using a customized pediatric magnetoencephalographic system. A videogame-like task was used to generate self-initiated right or left index finger movements in 17 healthy right-handed subjects (8 females, ages 3.2-4.8 years). We successfully identified spatiotemporal patterns of movement-related brain activity in 15/17 children using beamformer source analysis and surrogate MRI spatial normalization. Readiness fields in the contralateral sensorimotor cortex began ∼0.5 s prior to movement onset (motor field, MF), followed by transient movement-evoked fields (MEFs), similar to that observed during self-paced movements in adults, but slightly delayed and with inverted source polarities. We also observed modulation of mu (8-12 Hz) and beta (15-30 Hz) oscillations in sensorimotor cortex with movement, but with different timing and a stronger frequency band coupling compared to that observed in adults. Adult-like high-frequency (70-80 Hz) gamma bursts were detected at movement onset. All children showed activation of the right superior temporal gyrus that was independent of the side of movement, a response that has not been reported in adults. These results provide new insights into the development of movement-related brain function, for an age group in which no previous data exist. The results show that children under 5 years of age have markedly different patterns of movement-related brain activity in comparison to older children and adults, and indicate that significant maturational changes occur in the sensorimotor system between the preschool years and later childhood." @default.
- W1594773485 created "2016-06-24" @default.
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- W1594773485 date "2014-04-03" @default.
- W1594773485 modified "2023-10-14" @default.
- W1594773485 title "Movement-related neuromagnetic fields in preschool age children" @default.
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- W1594773485 doi "https://doi.org/10.1002/hbm.22518" @default.
- W1594773485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6869527" @default.
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- W1594773485 hasPublicationYear "2014" @default.
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