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- W1594780862 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CAThe aim of this study was to investigate prognostic significance of TRPM7 expression in nasopharyngeal carcinoma (NPC) and evaluate the association of TRPM7 with tumor invasion and metastasis. Immunohistochemical staining for TRPM7 was carried out on paraffin-embedded tissue sections from 206 NPC patients. The data was subjected to statistical analysis with respect to clinicopathological variables and survival. Real-time PCR and Western blot were used to assess the expression of TRPM7 in NPC cells. Small interfering RNA and construct transfection were used to knockdown and improve TRPM7 expression in NPC cells. TRPM7 was highly expressed in 102 out of 206 (49.5%) NPC cases. TRPM7 expression was significantly correlated with clinical stage, lymphatic and distant metastasis. The patients who had high TRPM7 expression showed a significantly lower 5 year survival rate than the patients who had low TRPM7 expression. TRPM7 might be an independent prognostic indicator for patient's survival. The cell lines with high metastatic potential expressed more TRPM7 than the cell lines with low metastatic potential. Moreover, the migratory and invasive potential of NPC cells was significantly decreased and increased by TRPM7 knockdown and overexpression. The study indicates that TRPM7 expression is inversely correlated with NPC patient survival and correlated with NPC invasion and metastasis.Note: This abstract was not presented at the meeting.Citation Format: Jian-Peng Chen, Guiqin Sun, Wei-Bo Wang, Cai-Xia Wang. TRPM7 expression predicts poor prognosis in patients with nasopharyngeal carcinoma and correlates with tumor metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 42. doi:10.1158/1538-7445.AM2014-42" @default.
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- W1594780862 date "2014-09-30" @default.
- W1594780862 modified "2023-09-27" @default.
- W1594780862 title "Abstract 42: TRPM7 expression predicts poor prognosis in patients with nasopharyngeal carcinoma and correlates with tumor metastasis" @default.
- W1594780862 doi "https://doi.org/10.1158/1538-7445.am2014-42" @default.
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