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- W1594860217 abstract "Abstract B lymphocyte stimulator (BLyS) signals via BR3 mediate selection and survival in the transitional, mature, and germinal center B cell pools. We have previously shown that treatment of mice with exogenous BLyS prior to immunization with HIV-1 envelope (Env) trimers improves neutralizing antibody breadth and potency. We are therefore investigating the hypothesis that broadly neutralizing B cell clonotypes are rare because of counter-selection at the transitional or germinal center checkpoints. Here we show that Env-specific murine B cells in pre-immune, germinal center, and memory B cell subsets can be visualized and tracked by flow cytometry using a biotinylated Env probe. Initial results indicate loss of Env+ B cells at both the transitional developmental stage and in the germinal center following immunization. As a first step in testing the feasibility of a BLyS pre-immunization treatment approach in nonhuman primates, we show that BLyS enhances survival of quiescent and dividing rhesus macaque B cells in vitro." @default.
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- W1594860217 date "2014-05-01" @default.
- W1594860217 modified "2023-10-16" @default.
- W1594860217 title "Potentially neutralizing B cell clonotypes are eliminated at peripheral selection checkpoints (LYM6P.768)" @default.
- W1594860217 doi "https://doi.org/10.4049/jimmunol.192.supp.131.5" @default.
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