Matches in SemOpenAlex for { <https://semopenalex.org/work/W1594875017> ?p ?o ?g. }
- W1594875017 abstract "Distinguishing between fetal and maternal inflammatory responses is necessary for understanding the immune interplay either side of the placenta. Fetal immunity reaches maturity during extrauterine life and while basic inflammatory responses afford a certain degree of protection, fetuses are vulnerable to infection. With the discovery of inflammasomes-intracellular scaffolds that facilitate the elaboration of reactions resulting in the release of mature interleukin-1β (IL-1β)-it is necessary to consider how inflammatory stimuli are processed. The purinergic P2X7 receptor located on haematopoietic cells is a key intermediary in signal transduction initiated at Toll-like receptors (TLR) terminating in release of the mature IL-1β product. We demonstrate herein that IL-1β release from fetal membranes and mononuclear cells isolated from cord, placental, and maternal blood, obtained at term, is P2X7- and caspase-1 dependent. The P2X7-dependent release of the cytokine, which was highest from choriodecidua, was attenuated by progesterone (P4), prolactin and an NFkB inhibitor. The NLRP3 inflammasome appears necessary for the processing of IL-1β in gestational tissues and leukocytes." @default.
- W1594875017 created "2016-06-24" @default.
- W1594875017 creator A5024343220 @default.
- W1594875017 creator A5057623936 @default.
- W1594875017 creator A5070079773 @default.
- W1594875017 creator A5088555249 @default.
- W1594875017 date "2015-06-23" @default.
- W1594875017 modified "2023-09-27" @default.
- W1594875017 title "Caspase-1-mediated cytokine release from gestational tissues, placental, and cord blood" @default.
- W1594875017 cites W132534127 @default.
- W1594875017 cites W141984575 @default.
- W1594875017 cites W150852725 @default.
- W1594875017 cites W1529674879 @default.
- W1594875017 cites W1594446519 @default.
- W1594875017 cites W1638271844 @default.
- W1594875017 cites W1680053970 @default.
- W1594875017 cites W1963558739 @default.
- W1594875017 cites W1966316405 @default.
- W1594875017 cites W1966872421 @default.
- W1594875017 cites W1967213726 @default.
- W1594875017 cites W1969773361 @default.
- W1594875017 cites W1973864194 @default.
- W1594875017 cites W1975755498 @default.
- W1594875017 cites W1977044826 @default.
- W1594875017 cites W1983038970 @default.
- W1594875017 cites W1985617803 @default.
- W1594875017 cites W1994190235 @default.
- W1594875017 cites W1994566614 @default.
- W1594875017 cites W1999723828 @default.
- W1594875017 cites W2000147555 @default.
- W1594875017 cites W2001393056 @default.
- W1594875017 cites W2004772755 @default.
- W1594875017 cites W2018698449 @default.
- W1594875017 cites W2025092283 @default.
- W1594875017 cites W2039416528 @default.
- W1594875017 cites W2043991526 @default.
- W1594875017 cites W2048847665 @default.
- W1594875017 cites W2050817030 @default.
- W1594875017 cites W2053287984 @default.
- W1594875017 cites W2058852263 @default.
- W1594875017 cites W2069822925 @default.
- W1594875017 cites W2075719860 @default.
- W1594875017 cites W2090859543 @default.
- W1594875017 cites W2092372960 @default.
- W1594875017 cites W2095068660 @default.
- W1594875017 cites W2106222929 @default.
- W1594875017 cites W2113841768 @default.
- W1594875017 cites W2123940909 @default.
- W1594875017 cites W2128548437 @default.
- W1594875017 cites W2131374338 @default.
- W1594875017 cites W2131707604 @default.
- W1594875017 cites W2134056170 @default.
- W1594875017 cites W2150594596 @default.
- W1594875017 cites W2150982004 @default.
- W1594875017 cites W2155932634 @default.
- W1594875017 cites W2157339124 @default.
- W1594875017 cites W2160784315 @default.
- W1594875017 cites W2162657919 @default.
- W1594875017 cites W4211217520 @default.
- W1594875017 doi "https://doi.org/10.3389/fphys.2015.00186" @default.
- W1594875017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4477139" @default.
- W1594875017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26157394" @default.
- W1594875017 hasPublicationYear "2015" @default.
- W1594875017 type Work @default.
- W1594875017 sameAs 1594875017 @default.
- W1594875017 citedByCount "11" @default.
- W1594875017 countsByYear W15948750172016 @default.
- W1594875017 countsByYear W15948750172017 @default.
- W1594875017 countsByYear W15948750172018 @default.
- W1594875017 countsByYear W15948750172019 @default.
- W1594875017 countsByYear W15948750172020 @default.
- W1594875017 countsByYear W15948750172022 @default.
- W1594875017 countsByYear W15948750172023 @default.
- W1594875017 crossrefType "journal-article" @default.
- W1594875017 hasAuthorship W1594875017A5024343220 @default.
- W1594875017 hasAuthorship W1594875017A5057623936 @default.
- W1594875017 hasAuthorship W1594875017A5070079773 @default.
- W1594875017 hasAuthorship W1594875017A5088555249 @default.
- W1594875017 hasBestOaLocation W15948750171 @default.
- W1594875017 hasConcept C172680121 @default.
- W1594875017 hasConcept C203014093 @default.
- W1594875017 hasConcept C2776914184 @default.
- W1594875017 hasConcept C2776953305 @default.
- W1594875017 hasConcept C2776955114 @default.
- W1594875017 hasConcept C2777209026 @default.
- W1594875017 hasConcept C2778690821 @default.
- W1594875017 hasConcept C2779234561 @default.
- W1594875017 hasConcept C2780197806 @default.
- W1594875017 hasConcept C2780914630 @default.
- W1594875017 hasConcept C28406088 @default.
- W1594875017 hasConcept C54355233 @default.
- W1594875017 hasConcept C57306754 @default.
- W1594875017 hasConcept C86803240 @default.
- W1594875017 hasConcept C8891405 @default.
- W1594875017 hasConcept C95444343 @default.
- W1594875017 hasConceptScore W1594875017C172680121 @default.
- W1594875017 hasConceptScore W1594875017C203014093 @default.
- W1594875017 hasConceptScore W1594875017C2776914184 @default.
- W1594875017 hasConceptScore W1594875017C2776953305 @default.
- W1594875017 hasConceptScore W1594875017C2776955114 @default.