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- W1595087607 abstract "Radioiodine (131I) is increasingly used as treatment for volume reduction of nontoxic, nodular goiter. A high dose of 131I is often needed because of low thyroid radioiodide uptake (RAIU). We investigated whether pretreatment with a single, low dose of recombinant human TSH (rhTSH; Thyrogen, Genzyme Transgenics Corp.) enhances RAIU in 15 patients with nontoxic, nodular goiter (14 women and 1 man; aged 61 ± 11 yr). Four patients were studied twice, and 1 patient was studied 3 times. RAIU was measured both under basal conditions and after pretreatment (im) with rhTSH, given either 2 h (0.01 mg; n = 7) or 24 h [0.01 mg (n = 7) or 0.03 mg (n = 7)] before 131I administration (20–40 μCi). Serum levels of TSH, free T4 (FT4), and total T3 were measured at 2, 5, 8, 24, 48, 72, 96, and 192 h after rhTSH administration. After administration of 0.01 mg rhTSH, serum TSH rose from 0.7 ± 0.5 to a peak level of 4.4 ± 1.1 mU/L (P 20% in 10 and by >30% in 6). In conclusion, pretreatment with a single, low dose of rhTSH in patients with nontoxic, nodular goiter increased RAIU considerably. Our observations hold promise that administration of rhTSH before 131I therapy for nontoxic, nodular goiter will allow treatment with lower doses of 131I in these patients. 2 .1 2.1 72 A dm iniration of a Sngle ow D se of Rcom bant H um an Thytropin Sigficantly Enances Tyroid Radiodide U pake in N otoxic N oular G oiter Proefschrift WA Nieuwlaat H2 23-03-2005 15:13 Pagina 72" @default.
- W1595087607 created "2016-06-24" @default.
- W1595087607 creator A5010413216 @default.
- W1595087607 date "2005-01-01" @default.
- W1595087607 modified "2023-09-27" @default.
- W1595087607 title "Recombinant Human Thyrotropin as an Adjuvant to Radioiodine Therapy for Nontoxic, Nodulal Goiter." @default.
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