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- W159517238 abstract "Publisher Summary Resident macrophages and lymphocytes within the human ovary suggest that these cells may be involved in ovarian endocrine function. In rat, macrophages are abundant in sites of follicular atresia and in corpus luteum development. This chapter presents a study to test null hypothesis that IL-lα does not influence progesterone secretion by human luteinized granulosa cells. The experiment described in this chapter showed that IL-lα produced biphasic effects on luteinized human granulosa cell basal progesterone production and inhibited hCG-stimulated progesterone production in the presence of WBC. IL-lα influences granulosa cell progesterone production through autocrine and paracrine interactions on adjacent WBC but does not appear to directly affect granulosa cell progesterone production at physiologic concentrations. The effects presented in this chapter are not secondary to alterations in cell proliferation or cytotoxicity but to direct effects on granulosa cell progesterone production. The data suggests that immune/inflammatory cells residing in the human ovary influence gonadal steroidogenesis through their secreted cytokines." @default.
- W159517238 created "2016-06-24" @default.
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- W159517238 date "1995-01-01" @default.
- W159517238 modified "2023-10-18" @default.
- W159517238 title "Interleukin-1α Inhibition of Luteinized Human Granulosa Cell Progesterone Production through Influences on Associated White Blood Cells" @default.
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- W159517238 doi "https://doi.org/10.1016/b978-0-12-571150-0.50025-1" @default.
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