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- W1595274098 abstract "We examined the influence of gender and gonadectomy on the plasma adrenocorticotropin (ACTH) response to intravenous administration of human recombinant interleukin (IL)-1beta (3 microg/kg) in the rat. For comparison, we also examined whether gender and gonadectomy affect ACTH secretion after immobilization stress (a 30-min period), which is a nonimmunological stressor. IL-1beta induced a significantly higher ACTH response in females than in males, and this sexual difference was abolished by gonadectomy in both sexes. By contrast, ACTH secretion after immobilization was statistically the same in males and females, but tended to be higher in gonadectomized males than in gonadectomized females. These results may suggest a dissociative regulation by gonadal steroids of IL-1beta- and immobilization-induced ACTH responses in the rat. The sexual difference in ACTH response to IL-1beta may represent another example of the sexually dimorphic immunological activity, which is known to be higher in females than in males." @default.
- W1595274098 created "2016-06-24" @default.
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- W1595274098 date "1996-01-01" @default.
- W1595274098 modified "2023-09-26" @default.
- W1595274098 title "Effects of Gender and Gonadectomy on ACTH Response to lnterleukin-1βin the Rat: Comparison with the Modulation of ACTH Response to Immobilization Stress" @default.
- W1595274098 doi "https://doi.org/10.1159/000097279" @default.
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