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- W1595426026 abstract "Abstract Objectives Enoxaparin is a low-molecular weight heparin (LMWH) widely used for the treatment of thrombosis and measured through a chromogenic assay (anti-Xa). The aim of this project was to investigate the impact of patient and sampling sources of variation on an anti-Xa assay for enoxaparin. Methods COATEST was used in accordance with manufacturer's instructions. A standard curve of LMWH concentration (0.1–1.0 IU/ml) was prepared. The shelf-life and freeze-thaw stability of Xa over a 6-month period were investigated. The effects of blood sample haemolysis and plasma antithrombin-III (AT) concentration were examined. Key findings The standard curve performed well with high accuracy (average bias of 8.1%) and precision (average CV of 2.8%). The shelf-life of Xa once reconstituted could be extended from 1 month to 4 months if aliquots were frozen at −20°C. Some loss of anti-Xa activity was observed on freeze-thawing (bias up to 25%). Haemolysis of 2.5% was found to interfere with the assay. AT level as low as 50% did not affect assay accuracy. Conclusions Xa standards when frozen immediately after reconstitution could be used for the following 4 months. Haemolysis interferes with the assay, but a 50% reduction in AT does not significantly affect the assay result." @default.
- W1595426026 created "2016-06-24" @default.
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- W1595426026 date "2014-12-31" @default.
- W1595426026 modified "2023-10-16" @default.
- W1595426026 title "Investigation of an anti-activated factor X (anti-Xa) assay for the quantification of enoxaparin in human plasma" @default.
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- W1595426026 doi "https://doi.org/10.1111/jphp.12333" @default.
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