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- W1595707286 abstract "Abstract The enantioselective transformation of a prochiral C=O double bond into the corresponding reduced CH–OH single bond plays a major role in asymmetric synthesis since this type of transformation represents a straightforward and an atom‐economical approach toward the synthesis of optically active alcohols. Owing to the importance of chiral alcohols in the field of chiral drug production, enantioselective ketone reduction also gained tremendous industrial interest. For the enantioselective reduction of ketones, numerous efficient catalytic routes have been developed up‐to‐date. As outstanding chemocatalytic technologies, metal‐catalyzed asymmetric hydrogenation of ketones and borane reduction are widely applied on industrial scale. Complementing these chemocatalytic technologies for the production of enantiomerically pure alcohols, enantioselective biocatalytic reduction of ketones turned out to be a highly efficient and competitive alternative technology. Notably, biocatalytic ketone technologies already made the “jump” from an interesting academic synthetic tool toward an industrially feasible technology platform. Besides high catalytic efficiency and excellent enantioselectivities, robustness and industrial large‐scale feasibility are further key features of enantioselective ketone reduction processes with biocatalysts. Thus, it is no surprise that the suitability for industrial purpose, in particular, for large‐scale manufacture of enantiomerically pure alcohols as drug intermediates, has been already demonstrated by a broad range of technical applications in the chemical and pharmaceutical industry." @default.
- W1595707286 created "2016-06-24" @default.
- W1595707286 creator A5040148990 @default.
- W1595707286 creator A5043185127 @default.
- W1595707286 creator A5072033344 @default.
- W1595707286 creator A5077386505 @default.
- W1595707286 date "2010-04-15" @default.
- W1595707286 modified "2023-10-10" @default.
- W1595707286 title "Enzyme‐Catalyzed Asymmetric Reduction of Ketones" @default.
- W1595707286 cites W1503273062 @default.
- W1595707286 cites W1522534030 @default.
- W1595707286 cites W1963580796 @default.
- W1595707286 cites W1968257532 @default.
- W1595707286 cites W1970281466 @default.
- W1595707286 cites W1973395192 @default.
- W1595707286 cites W1977712761 @default.
- W1595707286 cites W1979280514 @default.
- W1595707286 cites W1980011541 @default.
- W1595707286 cites W1980154991 @default.
- W1595707286 cites W1982549631 @default.
- W1595707286 cites W1986114417 @default.
- W1595707286 cites W1987485063 @default.
- W1595707286 cites W1991985473 @default.
- W1595707286 cites W1992392986 @default.
- W1595707286 cites W1992948593 @default.
- W1595707286 cites W1993997545 @default.
- W1595707286 cites W1994417202 @default.
- W1595707286 cites W2000357518 @default.
- W1595707286 cites W2001145775 @default.
- W1595707286 cites W2002072699 @default.
- W1595707286 cites W2003200957 @default.
- W1595707286 cites W2005702552 @default.
- W1595707286 cites W2006630744 @default.
- W1595707286 cites W2009658869 @default.
- W1595707286 cites W2010525314 @default.
- W1595707286 cites W2011803285 @default.
- W1595707286 cites W2015358637 @default.
- W1595707286 cites W2015722856 @default.
- W1595707286 cites W2015936762 @default.
- W1595707286 cites W2016364851 @default.
- W1595707286 cites W2017789201 @default.
- W1595707286 cites W2021805664 @default.
- W1595707286 cites W2022613754 @default.
- W1595707286 cites W2024579562 @default.
- W1595707286 cites W2027438788 @default.
- W1595707286 cites W2027915877 @default.
- W1595707286 cites W2029820978 @default.
- W1595707286 cites W2031671287 @default.
- W1595707286 cites W2036020448 @default.
- W1595707286 cites W2036023119 @default.
- W1595707286 cites W2037888244 @default.
- W1595707286 cites W2039309089 @default.
- W1595707286 cites W2046645212 @default.
- W1595707286 cites W2047530265 @default.
- W1595707286 cites W2048006177 @default.
- W1595707286 cites W2052219697 @default.
- W1595707286 cites W2052423010 @default.
- W1595707286 cites W2058611369 @default.
- W1595707286 cites W2058744259 @default.
- W1595707286 cites W2060520460 @default.
- W1595707286 cites W2071099078 @default.
- W1595707286 cites W2073138394 @default.
- W1595707286 cites W2088000975 @default.
- W1595707286 cites W2088125095 @default.
- W1595707286 cites W2090224411 @default.
- W1595707286 cites W2090265891 @default.
- W1595707286 cites W2090963244 @default.
- W1595707286 cites W2102821582 @default.
- W1595707286 cites W2103771125 @default.
- W1595707286 cites W2105526857 @default.
- W1595707286 cites W2105684939 @default.
- W1595707286 cites W2113723064 @default.
- W1595707286 cites W2119449094 @default.
- W1595707286 cites W2121265287 @default.
- W1595707286 cites W2127021370 @default.
- W1595707286 cites W2147732667 @default.
- W1595707286 cites W2149501066 @default.
- W1595707286 cites W2149588400 @default.
- W1595707286 cites W2150454507 @default.
- W1595707286 cites W2160198396 @default.
- W1595707286 cites W2171866871 @default.
- W1595707286 cites W2408461709 @default.
- W1595707286 cites W2494137754 @default.
- W1595707286 cites W2950683571 @default.
- W1595707286 cites W2950848188 @default.
- W1595707286 cites W2951059624 @default.
- W1595707286 cites W2951230724 @default.
- W1595707286 cites W2951308364 @default.
- W1595707286 cites W2951884495 @default.
- W1595707286 cites W2952706713 @default.
- W1595707286 cites W2952864270 @default.
- W1595707286 cites W4229778049 @default.
- W1595707286 cites W4251523880 @default.
- W1595707286 cites W4294555139 @default.
- W1595707286 cites W576590056 @default.
- W1595707286 cites W83001435 @default.
- W1595707286 doi "https://doi.org/10.1002/9780470054581.eib294" @default.
- W1595707286 hasPublicationYear "2010" @default.