FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1595737985> ?p ?o ?g. }

• W1595737985 abstract "Eukaryotic cells respond to heat stress by activating the transcription factor HSF1. In addition to its role in stress response, HSF1 also functions in protein homeostasis, aging, innate immunity, and cancer. Despite prominent HSF1 involvement in processes pertinent to human health and disease, there are still gaps in our understanding of HSF1. For example, controversy exists regarding the localization of HSF1, the identity of HSF1 regulators, and the function and conservation of heat-induced HSF1 stress granules. Many of the physiological roles for HSF1 have been defined using the model organism Caenorhabditis elegans, yet little is known about how the molecular and biological properties of HSF-1 in C. elegans compare to HSF1 in other organisms, including humans. To address these questions, we generated animals expressing physiological levels of a GFP-tagged C. elegans HSF-1 protein. We studied the localization of HSF-1::GFP in vivo and observed its behavior upon heat shock in C. elegans. Furthermore, we conducted a genome-wide, RNAi-based screen for regulators of an HSF-1-dependent, heat shock-inducible transcriptional reporter. We found that in live C. elegans, HSF-1 localizes predominantly to the nucleus before and after heat shock. Following heat shock, HSF-1 redistributes into subnuclear puncta that share many characteristics with human nuclear stress granules, including rapid formation, reversibility, and colocalization with markers of active transcription. Granule formation in worms was affected by growth temperature, implying physiological regulation of this process. From our RNAi screen, we identified 44 regulators of HSF-1 target gene expression, the majority of which were positive regulators. One RNAi clone, encoding the worm homolog of the post-translational modifier SUMO, resulted in hyper-induction of the HSF-1 target after heat shock. Our findings from the screen suggest that basal repression of HSF-1 under low-temperature conditions may be very strict, and that sumoylation may be involved in downregulation of the activated heat stress response pathway. Our data also support a model of constitutively nuclear C. elegans HSF-1 and present evidence that HSF-1 nuclear stress granule formation may be an evolutionarily conserved phenomenon." @default.
• W1595737985 created "2016-06-24" @default.
• W1595737985 creator A5084831697 @default.
• W1595737985 date "2013-01-01" @default.
• W1595737985 modified "2023-09-28" @default.
• W1595737985 title "Regulation and dymanic behavior of the heat shock transcription factor HSF-1 in C. elegans" @default.
• W1595737985 cites W105091175 @default.
• W1595737985 cites W1219854147 @default.
• W1595737985 cites W1479962123 @default.
• W1595737985 cites W1486450190 @default.
• W1595737985 cites W1488144878 @default.
• W1595737985 cites W1489733307 @default.
• W1595737985 cites W1491378726 @default.
• W1595737985 cites W1496827932 @default.
• W1595737985 cites W1511237419 @default.
• W1595737985 cites W151309050 @default.
• W1595737985 cites W1518351006 @default.
• W1595737985 cites W1527817144 @default.
• W1595737985 cites W1544587252 @default.
• W1595737985 cites W1621906674 @default.
• W1595737985 cites W1647302408 @default.
• W1595737985 cites W1648995497 @default.
• W1595737985 cites W1667728097 @default.
• W1595737985 cites W1715492285 @default.
• W1595737985 cites W1732882 @default.
• W1595737985 cites W1761531810 @default.
• W1595737985 cites W1825292303 @default.
• W1595737985 cites W1830116125 @default.
• W1595737985 cites W1847379925 @default.
• W1595737985 cites W1880638494 @default.
• W1595737985 cites W1881688083 @default.
• W1595737985 cites W1883113378 @default.
• W1595737985 cites W1909936605 @default.
• W1595737985 cites W1912190980 @default.
• W1595737985 cites W1925113696 @default.
• W1595737985 cites W1937676201 @default.
• W1595737985 cites W1944127002 @default.
• W1595737985 cites W1949720728 @default.
• W1595737985 cites W1954249603 @default.
• W1595737985 cites W1955953217 @default.
• W1595737985 cites W1961513222 @default.
• W1595737985 cites W1966943311 @default.
• W1595737985 cites W1967334476 @default.
• W1595737985 cites W1970061483 @default.
• W1595737985 cites W1971656831 @default.
• W1595737985 cites W1971819783 @default.
• W1595737985 cites W1973328141 @default.
• W1595737985 cites W1973733030 @default.
• W1595737985 cites W1975089320 @default.
• W1595737985 cites W1975195662 @default.
• W1595737985 cites W1976372760 @default.
• W1595737985 cites W1977449319 @default.
• W1595737985 cites W1977672942 @default.
• W1595737985 cites W1979344081 @default.
• W1595737985 cites W1980014349 @default.
• W1595737985 cites W1980291812 @default.
• W1595737985 cites W1981243923 @default.
• W1595737985 cites W1981256745 @default.
• W1595737985 cites W1981501274 @default.
• W1595737985 cites W1981593440 @default.
• W1595737985 cites W1981700185 @default.
• W1595737985 cites W1983953651 @default.
• W1595737985 cites W1985034089 @default.
• W1595737985 cites W1985425785 @default.
• W1595737985 cites W1987938397 @default.
• W1595737985 cites W1988011051 @default.
• W1595737985 cites W1988198388 @default.
• W1595737985 cites W1990000982 @default.
• W1595737985 cites W1990185604 @default.
• W1595737985 cites W1990863079 @default.
• W1595737985 cites W1991189921 @default.
• W1595737985 cites W1992021393 @default.
• W1595737985 cites W1993602761 @default.
• W1595737985 cites W1993915810 @default.
• W1595737985 cites W1994149899 @default.
• W1595737985 cites W1994486588 @default.
• W1595737985 cites W1996240289 @default.
• W1595737985 cites W1996781482 @default.
• W1595737985 cites W1997943303 @default.
• W1595737985 cites W1999769203 @default.
• W1595737985 cites W2000040240 @default.
• W1595737985 cites W2000177129 @default.
• W1595737985 cites W2000789682 @default.
• W1595737985 cites W2000995557 @default.
• W1595737985 cites W2001341780 @default.
• W1595737985 cites W2001610972 @default.
• W1595737985 cites W2003199010 @default.
• W1595737985 cites W2004722555 @default.
• W1595737985 cites W2005131012 @default.
• W1595737985 cites W2005289306 @default.
• W1595737985 cites W2006609702 @default.
• W1595737985 cites W2008481688 @default.
• W1595737985 cites W2008536823 @default.
• W1595737985 cites W2008904383 @default.
• W1595737985 cites W2009856824 @default.
• W1595737985 cites W2010021658 @default.
• W1595737985 cites W2010465475 @default.
• W1595737985 cites W2011277283 @default.
• W1595737985 cites W2012015460 @default.
• W1595737985 cites W2012648167 @default.

• next