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• W1595743575 abstract "Aging is of critical interest in the medical, health, and social domains, especially in developed countries and newly industrializing countries. Because muscle atrophy in elderly individuals can cause falls, its prevention is important. Moreover, prevention of agingrelated reduced skeletal muscle mass may allow a higher quality of life in the elderly, because reduced muscle function is linked to the occurrence of several chronic diseases (Handschin & Spiegelman, 2008). High-intensity resistance training effectively maintains muscle mass and strength, but rigorous training is difficult for elderly people (Seynnes et al., 2007). Acupuncture is a well-known traditional technique in eastern Asia that is used to maintain health and cure many diseases. Major acupuncture techniques utilize penetration of the skin by thin, solid metallic needles, which are manipulated manually or are stimulated electrically. This electrical needle stimulation is called electroacupuncture (EA) (Klein & Trachtenberg, 1997). EA is effective not only for pain but also for muscle problems, such as stiffness, exhaustion, and atrophy, in many patients including elderly people (Zhang, 2003). Acupuncture studies have reported the nerve routes of acupuncture signal transmission, effects via the spinal reflex, and reactions in the brain (Cho et al., 1998; Murase & Kawakita, 2000; Uchida et al., 2000). Figure 1 is a schematic diagram showing the routes of EA stimuli between treated points and organs. In a previous investigation on acupuncture, only a neural mechanism of pain reduction was clear; endogenous opioid (beta endorphin and enkephalin) is induced under the acupuncture anesthesia (Chung & Dickenson, 1980). However, the molecular mechanisms of other effects of acupuncture were as yet not defined (Acupuncture, 1997). Scientific evidence of efficacy is an important as for the CAM research, as for research in Western medicine. The enhancement of blood flow in target organs of acupuncture treatment, which is a major reason for the effectiveness of acupuncture (Niimi & Yuwono, 2000), cannot sufficiently explain the recovery of muscle from exhaustion because it is not clear how the supplied oxygen and nutrients would be used during the cellular recovery process. Many cellular and physiological processes are regulated at the transcription level of gene expression. The identification of genes specifically modulated during the process of acupuncture would provide an initial step toward elucidation of the underlying mechanisms of this technique." @default.
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• W1595743575 date "2011-09-06" @default.
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• W1595743575 title "Molecular Evidence: EA May Inhibit the Muscle Atrophy" @default.
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• W1595743575 doi "https://doi.org/10.5772/23450" @default.
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