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- W1595778825 abstract "The biochemical mechanism of resistance of the strains isolated from patients is described in the chapter. The mechanism of resistance to aminoglycosidic antibiotics was initiated by H. Umezawa and coworker. They first examined the reactions of kanamycin-neomycin acetyl transferase and of kanamycin-neomycin phosphate transferase. They described a method that gave enough of the enzyme reaction-products for structural determination, and they elucidated the structures of most of the reaction products. The chapter proves the direct relationship between the enzymes and the resistance; this was first shown by the fact that kanamycin C (which has no 6´-amino group to be acetylated) inhibits the resistant strain that produces the enzyme involved in acetylation of the 6´-amino group of kanamycins A and B. The reaction mechanism of kanamycin-neomycin phosphate transferase has been studied in detail, and the result permits prediction of the structures of derivatives active in inhibiting the growth of resistant organisms. The compounds thus synthesized are useful in the treatment of resistant infections, and are becoming more valuable as probes for further analysis of the biochemical mechanism of resistance. Determination of the structures of enzymes involved in resistance, in the future, give information useful in predicting new types of resistant organisms that may develop, and the structures of compounds active against future resistant strains." @default.
- W1595778825 created "2016-06-24" @default.
- W1595778825 creator A5013559735 @default.
- W1595778825 date "1974-01-01" @default.
- W1595778825 modified "2023-09-23" @default.
- W1595778825 title "Biochemical Mechanism of Resistance to Aminoglycoside Antibiotics" @default.
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- W1595778825 doi "https://doi.org/10.1016/s0065-2318(08)60265-6" @default.
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