Matches in SemOpenAlex for { <https://semopenalex.org/work/W1595928359> ?p ?o ?g. }
- W1595928359 endingPage "6" @default.
- W1595928359 startingPage "4610" @default.
- W1595928359 abstract "In contrast to other 12S-lipoxygenase (LOX) isoforms expressed in the skin of mice, epidermis-type (e) 12S-LOX was found to be transcriptionally down-regulated in the course of epidermal tumor development in NMRI mice. This may indicate that this enzyme is related to antitumorigenic rather than protumorigenic effects. To test this hypothesis, two transgenic mouse lines were generated that differentially expressed e12S-LOX under the control of the bovine keratin 6 promoter known to be constitutively up-regulated in mouse skin tumors. As compared with the wild-type, low transgene expression correlated with a decreased skin tumor response paralleled by an up-regulation of leukocyte-type 12S-LOX and an accumulation of the linoleic acid derivative 13S-hydroxyoctadecadienoic acid. In contrast, high transgene expression coincided with an increased tumor response paralleled by a strong keratin 6 promoter-driven up-regulation of the transgenic e12S-LOX and an accumulation of the arachidonic acid derivative 12S-hydroxyeicosatetraenoic acid as the predominant LOX product. These results indicate a complex interaction between different LOX isoforms and an opposite role of arachidonic acid and linoleic acid products in the modulation of skin carcinogenesis." @default.
- W1595928359 created "2016-06-24" @default.
- W1595928359 creator A5007487924 @default.
- W1595928359 creator A5010225884 @default.
- W1595928359 creator A5028824906 @default.
- W1595928359 creator A5055516089 @default.
- W1595928359 creator A5066040444 @default.
- W1595928359 creator A5080601032 @default.
- W1595928359 date "2002-08-15" @default.
- W1595928359 modified "2023-09-23" @default.
- W1595928359 title "Modulation of epidermal tumor development caused by targeted overexpression of epidermis-type 12S-lipoxygenase." @default.
- W1595928359 cites W107907750 @default.
- W1595928359 cites W1533414834 @default.
- W1595928359 cites W1543714797 @default.
- W1595928359 cites W1559034896 @default.
- W1595928359 cites W1562016580 @default.
- W1595928359 cites W1768840204 @default.
- W1595928359 cites W1872874293 @default.
- W1595928359 cites W1973598581 @default.
- W1595928359 cites W1974542837 @default.
- W1595928359 cites W1981661975 @default.
- W1595928359 cites W1985841114 @default.
- W1595928359 cites W1991735287 @default.
- W1595928359 cites W1995495200 @default.
- W1595928359 cites W2000912603 @default.
- W1595928359 cites W2003436829 @default.
- W1595928359 cites W2027831085 @default.
- W1595928359 cites W2034346812 @default.
- W1595928359 cites W2041768024 @default.
- W1595928359 cites W2049904704 @default.
- W1595928359 cites W2064300486 @default.
- W1595928359 cites W2069344265 @default.
- W1595928359 cites W2073145173 @default.
- W1595928359 cites W2074203890 @default.
- W1595928359 cites W2081324739 @default.
- W1595928359 cites W2081577661 @default.
- W1595928359 cites W2082613557 @default.
- W1595928359 cites W2084595890 @default.
- W1595928359 cites W2126242637 @default.
- W1595928359 cites W2126835057 @default.
- W1595928359 cites W2127658162 @default.
- W1595928359 cites W2135203659 @default.
- W1595928359 cites W2142783130 @default.
- W1595928359 cites W2146388445 @default.
- W1595928359 cites W2152311269 @default.
- W1595928359 cites W2154672973 @default.
- W1595928359 cites W2158444308 @default.
- W1595928359 cites W2163177774 @default.
- W1595928359 cites W2336169581 @default.
- W1595928359 cites W2346274178 @default.
- W1595928359 cites W2494193454 @default.
- W1595928359 cites W650915465 @default.
- W1595928359 cites W3115189511 @default.
- W1595928359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12183416" @default.
- W1595928359 hasPublicationYear "2002" @default.
- W1595928359 type Work @default.
- W1595928359 sameAs 1595928359 @default.
- W1595928359 citedByCount "6" @default.
- W1595928359 countsByYear W15959283592013 @default.
- W1595928359 countsByYear W15959283592015 @default.
- W1595928359 crossrefType "journal-article" @default.
- W1595928359 hasAuthorship W1595928359A5007487924 @default.
- W1595928359 hasAuthorship W1595928359A5010225884 @default.
- W1595928359 hasAuthorship W1595928359A5028824906 @default.
- W1595928359 hasAuthorship W1595928359A5055516089 @default.
- W1595928359 hasAuthorship W1595928359A5066040444 @default.
- W1595928359 hasAuthorship W1595928359A5080601032 @default.
- W1595928359 hasConcept C102230213 @default.
- W1595928359 hasConcept C104317684 @default.
- W1595928359 hasConcept C105702510 @default.
- W1595928359 hasConcept C141035611 @default.
- W1595928359 hasConcept C143065580 @default.
- W1595928359 hasConcept C153911025 @default.
- W1595928359 hasConcept C181199279 @default.
- W1595928359 hasConcept C185592680 @default.
- W1595928359 hasConcept C203014093 @default.
- W1595928359 hasConcept C207583985 @default.
- W1595928359 hasConcept C2776458125 @default.
- W1595928359 hasConcept C2776685179 @default.
- W1595928359 hasConcept C2776914184 @default.
- W1595928359 hasConcept C2778078955 @default.
- W1595928359 hasConcept C2780122803 @default.
- W1595928359 hasConcept C2780809830 @default.
- W1595928359 hasConcept C2780857362 @default.
- W1595928359 hasConcept C502942594 @default.
- W1595928359 hasConcept C53345823 @default.
- W1595928359 hasConcept C543025807 @default.
- W1595928359 hasConcept C54355233 @default.
- W1595928359 hasConcept C55493867 @default.
- W1595928359 hasConcept C555283112 @default.
- W1595928359 hasConcept C81241287 @default.
- W1595928359 hasConcept C86803240 @default.
- W1595928359 hasConceptScore W1595928359C102230213 @default.
- W1595928359 hasConceptScore W1595928359C104317684 @default.
- W1595928359 hasConceptScore W1595928359C105702510 @default.
- W1595928359 hasConceptScore W1595928359C141035611 @default.
- W1595928359 hasConceptScore W1595928359C143065580 @default.
- W1595928359 hasConceptScore W1595928359C153911025 @default.