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• W1596003835 abstract "Many tumours express tumour-specific antigens capable of being presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules. Current models of antigen presentation predict that the tumour cell itself should present its own MHC class I-restricted antigens to T cells. Earlier cross-priming experiments have demonstrated that at least some MHC class I-restricted antigens may also be presented by bystander cells. There is no detectable presentation of MHC class I-restricted tumour antigens by the tumour itself during priming of tumour-specific responses. The tumour antigens are presented exclusively by host bone marrow-derived cells. These results imply that an efficient mechanism exists in vivo for transfer of MHC I-restricted antigens to bone marrow-derived antigen presenting cells. They also suggest that HLA matching may not be critical in the clinical application of allogeneic tumour vaccines." @default.
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• W1596003835 date "2007-09-28" @default.
• W1596003835 modified "2023-09-29" @default.
• W1596003835 title "Bone Marrow-Derived Cells Present MHC Class I-Restricted Tumour Antigens in Priming of Antitumour Immune Responses" @default.
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• W1596003835 doi "https://doi.org/10.1002/9780470514672.ch15" @default.
• W1596003835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7796673" @default.
• W1596003835 hasPublicationYear "2007" @default.
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