Matches in SemOpenAlex for { <https://semopenalex.org/work/W1596267918> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1596267918 abstract "Phylloquinone (PK) is the primary dietary and circulating form of vitamin K. Low circulating PK has been associated with abnormal calcification of soft tissue. Because few studies have assessed the genetic component influencing circulating PK, we sought to identify common genetic variants associated with circulating PK concentrations by conducting a genome-wide association (GWA) meta-analysis of circulating PK in two populations of European descent from the Cohorts of Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Results from adjusted cohort-specific GWA analyses were meta-analyzed with inverse variance weights. No genome-wide significant associations were observed in the meta-analysis (n = 2,138). We found nominal associations (P<1×10−6) on five independent loci. These results suggest that the APOA1C3/A4/A5 gene cluster, involved in triglyceride transport, CYP4F2, involved in vitamin metabolism, COL22A1, a collagen gene, CTNAA2, a catenin gene, and CDO1, a cysteine dioxygenase gene, are candidate genes that may be associated with serum PK. Given the multiple determinants of circulating PK and small sample size of the current study, further investigation with a larger sample is warranted." @default.
- W1596267918 created "2016-06-24" @default.
- W1596267918 creator A5000765323 @default.
- W1596267918 creator A5006794336 @default.
- W1596267918 creator A5015228664 @default.
- W1596267918 creator A5018093575 @default.
- W1596267918 creator A5041676520 @default.
- W1596267918 creator A5043107881 @default.
- W1596267918 creator A5066734451 @default.
- W1596267918 creator A5067387552 @default.
- W1596267918 creator A5079276216 @default.
- W1596267918 date "2014-04-01" @default.
- W1596267918 modified "2023-09-27" @default.
- W1596267918 title "Meta‐analysis of genome‐wide association studies for circulating phylloquinone (818.9)" @default.
- W1596267918 doi "https://doi.org/10.1096/fasebj.28.1_supplement.818.9" @default.
- W1596267918 hasPublicationYear "2014" @default.
- W1596267918 type Work @default.
- W1596267918 sameAs 1596267918 @default.
- W1596267918 citedByCount "0" @default.
- W1596267918 crossrefType "journal-article" @default.
- W1596267918 hasAuthorship W1596267918A5000765323 @default.
- W1596267918 hasAuthorship W1596267918A5006794336 @default.
- W1596267918 hasAuthorship W1596267918A5015228664 @default.
- W1596267918 hasAuthorship W1596267918A5018093575 @default.
- W1596267918 hasAuthorship W1596267918A5041676520 @default.
- W1596267918 hasAuthorship W1596267918A5043107881 @default.
- W1596267918 hasAuthorship W1596267918A5066734451 @default.
- W1596267918 hasAuthorship W1596267918A5067387552 @default.
- W1596267918 hasAuthorship W1596267918A5079276216 @default.
- W1596267918 hasConcept C104317684 @default.
- W1596267918 hasConcept C106208931 @default.
- W1596267918 hasConcept C126322002 @default.
- W1596267918 hasConcept C135763542 @default.
- W1596267918 hasConcept C153209595 @default.
- W1596267918 hasConcept C186413461 @default.
- W1596267918 hasConcept C54355233 @default.
- W1596267918 hasConcept C69991583 @default.
- W1596267918 hasConcept C71924100 @default.
- W1596267918 hasConcept C86803240 @default.
- W1596267918 hasConcept C95190672 @default.
- W1596267918 hasConceptScore W1596267918C104317684 @default.
- W1596267918 hasConceptScore W1596267918C106208931 @default.
- W1596267918 hasConceptScore W1596267918C126322002 @default.
- W1596267918 hasConceptScore W1596267918C135763542 @default.
- W1596267918 hasConceptScore W1596267918C153209595 @default.
- W1596267918 hasConceptScore W1596267918C186413461 @default.
- W1596267918 hasConceptScore W1596267918C54355233 @default.
- W1596267918 hasConceptScore W1596267918C69991583 @default.
- W1596267918 hasConceptScore W1596267918C71924100 @default.
- W1596267918 hasConceptScore W1596267918C86803240 @default.
- W1596267918 hasConceptScore W1596267918C95190672 @default.
- W1596267918 hasIssue "S1" @default.
- W1596267918 hasLocation W15962679181 @default.
- W1596267918 hasOpenAccess W1596267918 @default.
- W1596267918 hasPrimaryLocation W15962679181 @default.
- W1596267918 hasRelatedWork W2028523909 @default.
- W1596267918 hasRelatedWork W2137493625 @default.
- W1596267918 hasRelatedWork W2153898919 @default.
- W1596267918 hasRelatedWork W2157230184 @default.
- W1596267918 hasRelatedWork W2589043292 @default.
- W1596267918 hasRelatedWork W2730428919 @default.
- W1596267918 hasRelatedWork W2953466646 @default.
- W1596267918 hasRelatedWork W3047075125 @default.
- W1596267918 hasRelatedWork W4205545748 @default.
- W1596267918 hasRelatedWork W2523468413 @default.
- W1596267918 hasVolume "28" @default.
- W1596267918 isParatext "false" @default.
- W1596267918 isRetracted "false" @default.
- W1596267918 magId "1596267918" @default.
- W1596267918 workType "article" @default.