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• W1596269212 endingPage "d694" @default.
• W1596269212 startingPage "d694" @default.
• W1596269212 abstract "Magnesium is the fourth most abundant cation in the body and the second most common cation in the intracellular fluid. It is the kidney that provides the most sensitive control for magnesium balance. About a 80% of the total serum magnesium is ultrafilterable through the glomerular membrane. In all of the mammalian species studied to date, the proximal tubule of the adult animal reabsorbs only a small fraction, 10-15%, of the filtered magnesium. Unlike the adult proximal convoluted tubule that of young rats (aged 13-15 days) reabsorbs 50-60% of filtered magnesium along the proximal tubule together with sodium, calcium, and water. Micropuncture experiments, in every species studied to date, indicates that a large part (approximately 60%) of the filtered magnesium is reabsorbed in the loop of Henle. Magnesium reabsorption in the loop occurs within the cortical thick ascending limb (cTAL) by passive means driven by the transepithelial voltage through the paracellular pathway. Micropuncture experiments have clearly showed that the superficial distal tubule reabsorbs significant amounts of magnesium. Unlike the thick ascending limb of the loop of Henle, magnesium reabsorption in the distal tubule is transcellular and active in nature. Many hormones and nonhormonal factors influence renal magnesium reabsorption to variable extent in the cTAL and distal tubule. Moreover, nonhormonal factors may have important implications on hormonal controls of renal magnesium conservation. Dietary magnesium restriction leads to renal magnesium conservation with diminished urinary magnesium excretion. Adaptation of magnesium transport with dietary magnesium restriction occurs in both the cTAL and distal tubule. Elevation of plasma magnesium or calcium concentration inhibits magnesium and calcium reabsorption leading to hypermagnesiuria and hypercalciuria. The identification of an extracellular Ca2+/Mg2+ -sensing receptor located on the peritubular side of cTAL and distal tubule cells explains this phenomenon. Loop diuretics, such as furosemide and bumetanide, diminish salt absorption in the cTAL whereas the distally acting diuretics, amiloride and chlorothiazide stimulate magnesium reabsorption within the distal convoluted tubule. Finally, metabolic acidosis, potassium depletion or phosphate restriction can diminish magnesium reabsorption within the loop and distal tubule. Research in the 90's have greatly contributed to our understanding of renal magnesium handling." @default.
• W1596269212 created "2016-06-24" @default.
• W1596269212 creator A5003383964 @default.
• W1596269212 creator A5029946461 @default.
• W1596269212 date "2000-01-01" @default.
• W1596269212 modified "2023-10-17" @default.
• W1596269212 title "Epithelial magnesium transport and regulation by the kidney" @default.
• W1596269212 cites W1753116283 @default.
• W1596269212 cites W1857677349 @default.
• W1596269212 cites W1882996137 @default.
• W1596269212 cites W1948536800 @default.
• W1596269212 cites W1979905226 @default.
• W1596269212 cites W1982934768 @default.
• W1596269212 cites W1986033928 @default.
• W1596269212 cites W1987787213 @default.
• W1596269212 cites W1988186319 @default.
• W1596269212 cites W1989156208 @default.
• W1596269212 cites W1993191224 @default.
• W1596269212 cites W1994804197 @default.
• W1596269212 cites W2000227813 @default.
• W1596269212 cites W2008168013 @default.
• W1596269212 cites W2009291880 @default.
• W1596269212 cites W2009441758 @default.
• W1596269212 cites W2009783633 @default.
• W1596269212 cites W2013154098 @default.
• W1596269212 cites W2019761155 @default.
• W1596269212 cites W2020128617 @default.
• W1596269212 cites W2023867671 @default.
• W1596269212 cites W2028102664 @default.
• W1596269212 cites W2028378191 @default.
• W1596269212 cites W2034288966 @default.
• W1596269212 cites W2040814486 @default.
• W1596269212 cites W2042484533 @default.
• W1596269212 cites W2043207194 @default.
• W1596269212 cites W2044146267 @default.
• W1596269212 cites W2048769239 @default.
• W1596269212 cites W2055335409 @default.
• W1596269212 cites W2058316297 @default.
• W1596269212 cites W2071563184 @default.
• W1596269212 cites W2072102799 @default.
• W1596269212 cites W2075043133 @default.
• W1596269212 cites W2077152515 @default.
• W1596269212 cites W2077973233 @default.
• W1596269212 cites W2078191848 @default.
• W1596269212 cites W2079130054 @default.
• W1596269212 cites W2082023956 @default.
• W1596269212 cites W2082379191 @default.
• W1596269212 cites W2084748927 @default.
• W1596269212 cites W2088542427 @default.
• W1596269212 cites W2091671897 @default.
• W1596269212 cites W2102108938 @default.
• W1596269212 cites W2130688464 @default.
• W1596269212 cites W2139403483 @default.
• W1596269212 cites W2145977668 @default.
• W1596269212 cites W2151821871 @default.
• W1596269212 cites W2159813375 @default.
• W1596269212 cites W2163154369 @default.
• W1596269212 cites W2175189370 @default.
• W1596269212 cites W2181632829 @default.
• W1596269212 cites W2195790549 @default.
• W1596269212 cites W2258597631 @default.
• W1596269212 cites W2265684033 @default.
• W1596269212 cites W2273862599 @default.
• W1596269212 cites W2285719864 @default.
• W1596269212 cites W2291344631 @default.
• W1596269212 cites W2297641231 @default.
• W1596269212 cites W2337270791 @default.
• W1596269212 cites W2344199028 @default.
• W1596269212 cites W2398239885 @default.
• W1596269212 cites W2404889784 @default.
• W1596269212 cites W2409127524 @default.
• W1596269212 cites W2410128019 @default.
• W1596269212 cites W2411811141 @default.
• W1596269212 cites W2413556482 @default.
• W1596269212 cites W2415921715 @default.
• W1596269212 cites W2416772452 @default.
• W1596269212 cites W2417163451 @default.
• W1596269212 cites W2433218219 @default.
• W1596269212 cites W2610628962 @default.
• W1596269212 cites W2622765920 @default.
• W1596269212 cites W97851265 @default.
• W1596269212 cites W2395427458 @default.
• W1596269212 doi "https://doi.org/10.2741/quamme" @default.
• W1596269212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10922295" @default.
• W1596269212 hasPublicationYear "2000" @default.
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