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- W1596327790 abstract "Publisher Summary This chapter discuses the classification of nervous system malformations. Because of the limitations of both pure morphological and pure genetic approaches to the classification of nervous system malformations, a combined scheme is proposed in the chapter that integrates the two and enables the recognition of the gradients of genetic expression, whether or not the specific defective gene is known. It also provides the flexibility needed for future revision and for the inclusion of nongenetic developmental defects acquired during fetal and early postnatal development. This classification has undergone several revisions and the chapter offers yet another update to incorporate new data and new understanding of some cerebral dysgeneses, in particular, those associated with neural crest defects and neurocutaneous syndromes. However, some malformations may not be of genetic origin and may be secondary to acquired defects in the developing brain, as might be induced by congenital infections, or by ischemic episodes in the fetus that cause infarcts in the white matter, which interrupt radial glial fibers that guide migratory neuroblasts. Any reliable classification scheme of the dysgeneses of the nervous system must have flexibility to change and to incorporate nongenetic malformations." @default.
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- W1596327790 date "2007-01-01" @default.
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- W1596327790 title "Axes and gradients of the neural tube for a morphological/molecular genetic classification of nervous system malformations" @default.
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- W1596327790 doi "https://doi.org/10.1016/s0072-9752(07)87001-1" @default.
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