FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1596394209> ?p ?o ?g. }

• W1596394209 endingPage "3506" @default.
• W1596394209 startingPage "3495" @default.
• W1596394209 abstract "Gap junction (GJ) channels formed from connexin (Cx) proteins provide a direct pathway for electrical and metabolic cell–cell communication exhibiting high sensitivity to intracellular pH (pH(i)). We examined pH(i)-dependent modulation of junctional conductance (g(j)) of GJs formed of Cx26, mCx30.2, Cx36, Cx40, Cx43, Cx45, Cx46, Cx47 and Cx50 by reagents representing several distinct groups of uncouplers, such as long carbon chain alkanols (LCCAs), arachidonic acid, carbenoxolone, isoflurane, flufenamic acid and mefloquine. We demonstrate that alkalization by NH4Cl to pH ∼8 increased g(j) in cells expressing mCx30.2 and Cx45, yet did not affect g(j) of Cx26, Cx40, Cx46, Cx47 and Cx50 and decreased it in Cx43 and Cx36 GJs. Unexpectedly, cells expressing Cx45, but not other Cxs, exhibited full coupling recovery after alkalization with NH4Cl under the continuous presence of LCCAs, isoflurane and mefloquine. There was no coupling recovery by alkalization in the presence of arachidonic acid, carbenoxolone and flufenamic acid. In cells expressing Cx45, IC50 for octanol was 0.1, 0.25 and 2.68 mm at pH(i) values of 6.9, 7.2 and 8.1, respectively. Histidine modification of Cx45 protein by N-bromosuccinimide reduced the coupling-promoting effect of NH4Cl as well as the uncoupling effect of octanol. This suggests that LCCAs and some other uncouplers may act through the formation of hydrogen bonds with the as-of-yet unidentified histidine/s of the Cx45 GJ channel protein." @default.
• W1596394209 created "2016-06-24" @default.
• W1596394209 creator A5006044985 @default.
• W1596394209 creator A5009460737 @default.
• W1596394209 creator A5009981318 @default.
• W1596394209 creator A5036209959 @default.
• W1596394209 creator A5067481874 @default.
• W1596394209 date "2011-07-15" @default.
• W1596394209 modified "2023-10-02" @default.
• W1596394209 title "pH-dependent modulation of connexin-based gap junctional uncouplers" @default.
• W1596394209 cites W1505485126 @default.
• W1596394209 cites W1596122743 @default.
• W1596394209 cites W1987770068 @default.
• W1596394209 cites W1990623062 @default.
• W1596394209 cites W2011908808 @default.
• W1596394209 cites W2012654459 @default.
• W1596394209 cites W2013736577 @default.
• W1596394209 cites W2013817450 @default.
• W1596394209 cites W2021701700 @default.
• W1596394209 cites W2021879636 @default.
• W1596394209 cites W2027254482 @default.
• W1596394209 cites W2027423337 @default.
• W1596394209 cites W2031449089 @default.
• W1596394209 cites W2033032294 @default.
• W1596394209 cites W2033936610 @default.
• W1596394209 cites W2038245509 @default.
• W1596394209 cites W2049363516 @default.
• W1596394209 cites W2050435114 @default.
• W1596394209 cites W2073203246 @default.
• W1596394209 cites W2083786873 @default.
• W1596394209 cites W2086751308 @default.
• W1596394209 cites W2087742793 @default.
• W1596394209 cites W2102973847 @default.
• W1596394209 cites W2103255264 @default.
• W1596394209 cites W2104390075 @default.
• W1596394209 cites W2119516090 @default.
• W1596394209 cites W2129894115 @default.
• W1596394209 cites W2131528678 @default.
• W1596394209 cites W2132478632 @default.
• W1596394209 cites W2141361237 @default.
• W1596394209 cites W2153921203 @default.
• W1596394209 cites W2161194374 @default.
• W1596394209 cites W2166809896 @default.
• W1596394209 cites W2256783719 @default.
• W1596394209 cites W2408065810 @default.
• W1596394209 cites W968293245 @default.
• W1596394209 doi "https://doi.org/10.1113/jphysiol.2011.209072" @default.
• W1596394209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3167113" @default.
• W1596394209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21606109" @default.
• W1596394209 hasPublicationYear "2011" @default.
• W1596394209 type Work @default.
• W1596394209 sameAs 1596394209 @default.
• W1596394209 citedByCount "29" @default.
• W1596394209 countsByYear W15963942092012 @default.
• W1596394209 countsByYear W15963942092013 @default.
• W1596394209 countsByYear W15963942092014 @default.
• W1596394209 countsByYear W15963942092015 @default.
• W1596394209 countsByYear W15963942092016 @default.
• W1596394209 countsByYear W15963942092017 @default.
• W1596394209 countsByYear W15963942092018 @default.
• W1596394209 countsByYear W15963942092020 @default.
• W1596394209 countsByYear W15963942092021 @default.
• W1596394209 countsByYear W15963942092022 @default.
• W1596394209 countsByYear W15963942092023 @default.
• W1596394209 crossrefType "journal-article" @default.
• W1596394209 hasAuthorship W1596394209A5006044985 @default.
• W1596394209 hasAuthorship W1596394209A5009460737 @default.
• W1596394209 hasAuthorship W1596394209A5009981318 @default.
• W1596394209 hasAuthorship W1596394209A5036209959 @default.
• W1596394209 hasAuthorship W1596394209A5067481874 @default.
• W1596394209 hasBestOaLocation W15963942092 @default.
• W1596394209 hasConcept C12554922 @default.
• W1596394209 hasConcept C127413603 @default.
• W1596394209 hasConcept C131584629 @default.
• W1596394209 hasConcept C158157758 @default.
• W1596394209 hasConcept C185592680 @default.
• W1596394209 hasConcept C2776724001 @default.
• W1596394209 hasConcept C2778460671 @default.
• W1596394209 hasConcept C2780228694 @default.
• W1596394209 hasConcept C2780961449 @default.
• W1596394209 hasConcept C515207424 @default.
• W1596394209 hasConcept C55493867 @default.
• W1596394209 hasConcept C78519656 @default.
• W1596394209 hasConcept C79879829 @default.
• W1596394209 hasConcept C86803240 @default.
• W1596394209 hasConceptScore W1596394209C12554922 @default.
• W1596394209 hasConceptScore W1596394209C127413603 @default.
• W1596394209 hasConceptScore W1596394209C131584629 @default.
• W1596394209 hasConceptScore W1596394209C158157758 @default.
• W1596394209 hasConceptScore W1596394209C185592680 @default.
• W1596394209 hasConceptScore W1596394209C2776724001 @default.
• W1596394209 hasConceptScore W1596394209C2778460671 @default.
• W1596394209 hasConceptScore W1596394209C2780228694 @default.
• W1596394209 hasConceptScore W1596394209C2780961449 @default.
• W1596394209 hasConceptScore W1596394209C515207424 @default.
• W1596394209 hasConceptScore W1596394209C55493867 @default.
• W1596394209 hasConceptScore W1596394209C78519656 @default.
• W1596394209 hasConceptScore W1596394209C79879829 @default.

• next