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- W1596442600 abstract "Abstract Stimulator cells for the allogeneic MLR are dendritic cells but not macrophages (M phi). M phi, however, enhance the MLR initiated by relatively low doses of dendritic cells. The present report demonstrates that the enhancement of the MLR is mediated by two factors produced by M phi. One is IL-1, inasmuch as it has a Mr approximately 15 kDa, and both partially purified IL-1 and rIL-1 also enhance the MLR. The other has been identified as granulocyte-macrophage (GM)-CSF. It had a Mr approximately 25 kDa, and is reproduced by rGM-CSF. Moreover, the MLR-enhancing activity of both the 25-kDa molecule and rGM-CSF have been neutralized by anti-GM-CSF antiserum. Both IL-1 and GM-CSF have autonomous enhancing activity, but they collaborate with each other in enhancing the MLR. Both factors act on DC to augment their stimulatory activity for allogeneic T lymphocytes." @default.
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- W1596442600 date "1989-03-15" @default.
- W1596442600 modified "2023-10-11" @default.
- W1596442600 title "Macrophage factors which enhance the mixed leukocyte reaction initiated by dendritic cells." @default.
- W1596442600 doi "https://doi.org/10.4049/jimmunol.142.6.1834" @default.
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