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- W159645890 startingPage "35" @default.
- W159645890 abstract "Glycoprotein (GP) IIb-IIIa [αIIbβ3 in integrin nomenclature (1)], the most abundant protein on the platelet surface, is the primary receptor mediating platelet aggregation, a process central to acute arterial thrombosis and to hemostasis. Indeed, its central role in aggregation positions GP IIb-IIIa at the heart of thrombosis and has directed aggressive strategies into developing a new class of drugs, termed GP IIb-IIIa antagonists, which block the binding of adhesive proteins to GP IIb-IIIa thus preventing platelet aggregation. GP IIb-IIIa anatagonists have been shown to therapeutically regulate platelet function to prevent, for example, the thrombotic complications associated with coronary artery disease (2–4). The pivotal role that GP IIb-IIIa serves in platelet aggregation arises due to the dynamic nature of this receptor, which displays several functional activities that are important not only in understanding how this receptor is involved in platelet aggregation and thrombosis, but also, ultimately, for understanding how GP IIb-IIIa antagonists can be more effectively utilized to optimize their antithrombotic activities." @default.
- W159645890 created "2016-06-24" @default.
- W159645890 creator A5000641347 @default.
- W159645890 creator A5074114064 @default.
- W159645890 date "1999-01-01" @default.
- W159645890 modified "2023-10-18" @default.
- W159645890 title "Glycoprotein IIb-IIIa in Platelet Aggregation and Acute Arterial Thrombosis" @default.
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