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- W1596558783 abstract "Abstract N-myc downstream-regulated gene 2 (NDRG2) has been characterized as a regulator of dendritic cell differentiation. In this study, we show that NDRG2 overexpression inhibits the differentiation of U937 cells into osteoclasts in response to stimulation with LPS, TNF-α, 1α,25-dihydroxyvitamin D3 (1,25D3), or a combination of macrophage colony-stimulating factor (M-CSF) and soluble receptor activator of NF-κB ligand (RANKL). U937 cells stably expressing NDRG2 display reduced tartrate-resistant acid phosphatase (TRAP) activity, as well as defects in F-actin ring formation and resorption pit formation. Furthermore, NDRG2 expression significantly suppresses the expression of genes that are crucial to the proliferation, survival, differentiation, and function of osteoclasts, including c-Fos, Atp6v0d2, RANK, cathepsin K, αv integrin, and MMP-9. Activation of ERK1/2 and p38 is also inhibited by NDRG2 expression during osteoclastogenesis, and the inhibition of osteoclastogenesis by NDRG2 correlates with by down-regulation of the expression of the PU.1 transcription factor. Finally, NDRG2 expression inhibited the differentiation of bone marrow cells and macrophages into osteoclasts, as judged by the failure of these cells to develop giant F-actin rings and resorption pits. Taken together, our results suggest that expression of NDRG2 potentially inhibits osteoclast differentiation and plays a role in modulating the signal transduction pathway responsible for osteoclastogenesis." @default.
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- W1596558783 date "2012-05-01" @default.
- W1596558783 modified "2023-10-16" @default.
- W1596558783 title "NDRG2 expression suppresses osteoclast differentiation by down-regulating PU.1 (167.6)" @default.
- W1596558783 doi "https://doi.org/10.4049/jimmunol.188.supp.167.6" @default.
- W1596558783 hasPublicationYear "2012" @default.
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