FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1596598368> ?p ?o ?g. }

• W1596598368 endingPage "16454" @default.
• W1596598368 startingPage "16450" @default.
• W1596598368 abstract "The juxtamembrane region of the insulin receptor (IR) beta-subunit contains an unphosphorylated tyrosyl residue (Tyr960) that is essential for insulin-stimulated tyrosyl phosphorylation of some endogenous substrates and certain biological responses (White, M.F., Livingston, J.N., Backer, J.M., Lauris, V., Dull, T.J., Ullrich, A., and Kahn, C.R. (1988) Cell 54, 641-649). Tyrosyl residues in the juxtamembrane region of some plasma membrane receptors have been shown to be required for their internalization. In addition, a juxtamembrane tyrosine in the context of the sequence NPXY [corrected] is required for the coated pit-mediated internalization of the low density lipoprotein receptor. To examine the role of the juxtamembrane region of the insulin receptor during receptor-mediated endocytosis, we have studied the internalization of insulin by Chinese hamster ovary (CHO) cells expressing two mutant receptors: IRF960, in which Tyr960 has been substituted with phenylalanine, and IR delta 960, in which 12 amino acids (Ala954-Asp965), including the putative consensus sequence NPXY [corrected], were deleted. Although the in vivo autophosphorylation of IRF960 and IR delta 960 was similar to wild type, neither mutant could phosphorylate the endogenous substrate pp185. CHO/IRF960 cells internalized insulin normally whereas the intracellular accumulation of insulin by CHO/IR delta 960 cells was 20-30% of wild-type. However, insulin internalization in the CHO/IR delta 960 cells was consistently more rapid than that occurring in CHO cells expressing kinase-deficient receptors (CHO/IRA1018). The degradation of insulin was equally impaired in CHO/IR delta 960 and CHO/IRA1018 cells. These data show that the juxtamembrane region of the insulin receptor contains residues essential for insulin-stimulated internalization and suggest that the sequence NPXY [corrected] may play a general role in directing the internalization of cell surface receptors." @default.
• W1596598368 created "2016-06-24" @default.
• W1596598368 creator A5032267904 @default.
• W1596598368 creator A5051737440 @default.
• W1596598368 creator A5054486557 @default.
• W1596598368 creator A5078843999 @default.
• W1596598368 creator A5087367146 @default.
• W1596598368 date "1990-09-01" @default.
• W1596598368 modified "2023-10-15" @default.
• W1596598368 title "Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit." @default.
• W1596598368 cites W115701967 @default.
• W1596598368 cites W1503598995 @default.
• W1596598368 cites W1505075493 @default.
• W1596598368 cites W1533778697 @default.
• W1596598368 cites W1577741430 @default.
• W1596598368 cites W1583703772 @default.
• W1596598368 cites W1590657000 @default.
• W1596598368 cites W1593895189 @default.
• W1596598368 cites W1607784649 @default.
• W1596598368 cites W1624505911 @default.
• W1596598368 cites W1668568781 @default.
• W1596598368 cites W1807118481 @default.
• W1596598368 cites W1848295934 @default.
• W1596598368 cites W1965371391 @default.
• W1596598368 cites W1966297980 @default.
• W1596598368 cites W1970280322 @default.
• W1596598368 cites W1972960760 @default.
• W1596598368 cites W1975382404 @default.
• W1596598368 cites W1984159784 @default.
• W1596598368 cites W1991710558 @default.
• W1596598368 cites W2007796735 @default.
• W1596598368 cites W2015707895 @default.
• W1596598368 cites W2030156849 @default.
• W1596598368 cites W2040087470 @default.
• W1596598368 cites W2043813981 @default.
• W1596598368 cites W2044343226 @default.
• W1596598368 cites W2049583570 @default.
• W1596598368 cites W2067789475 @default.
• W1596598368 cites W2073705445 @default.
• W1596598368 cites W2080199365 @default.
• W1596598368 cites W2082091164 @default.
• W1596598368 cites W2095262331 @default.
• W1596598368 cites W2101959682 @default.
• W1596598368 cites W2132647577 @default.
• W1596598368 cites W2138270253 @default.
• W1596598368 cites W2161163260 @default.
• W1596598368 cites W4293247451 @default.
• W1596598368 doi "https://doi.org/10.1016/s0021-9258(17)46243-0" @default.
• W1596598368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2204623" @default.
• W1596598368 hasPublicationYear "1990" @default.
• W1596598368 type Work @default.
• W1596598368 sameAs 1596598368 @default.
• W1596598368 citedByCount "124" @default.
• W1596598368 countsByYear W15965983682013 @default.
• W1596598368 countsByYear W15965983682015 @default.
• W1596598368 countsByYear W15965983682016 @default.
• W1596598368 countsByYear W15965983682017 @default.
• W1596598368 countsByYear W15965983682018 @default.
• W1596598368 countsByYear W15965983682019 @default.
• W1596598368 countsByYear W15965983682020 @default.
• W1596598368 countsByYear W15965983682021 @default.
• W1596598368 countsByYear W15965983682022 @default.
• W1596598368 countsByYear W15965983682023 @default.
• W1596598368 crossrefType "journal-article" @default.
• W1596598368 hasAuthorship W1596598368A5032267904 @default.
• W1596598368 hasAuthorship W1596598368A5051737440 @default.
• W1596598368 hasAuthorship W1596598368A5054486557 @default.
• W1596598368 hasAuthorship W1596598368A5078843999 @default.
• W1596598368 hasAuthorship W1596598368A5087367146 @default.
• W1596598368 hasBestOaLocation W15965983681 @default.
• W1596598368 hasConcept C104292427 @default.
• W1596598368 hasConcept C104317684 @default.
• W1596598368 hasConcept C112446052 @default.
• W1596598368 hasConcept C134018914 @default.
• W1596598368 hasConcept C139770010 @default.
• W1596598368 hasConcept C164083038 @default.
• W1596598368 hasConcept C167625842 @default.
• W1596598368 hasConcept C170493617 @default.
• W1596598368 hasConcept C185592680 @default.
• W1596598368 hasConcept C185967709 @default.
• W1596598368 hasConcept C197902417 @default.
• W1596598368 hasConcept C199360897 @default.
• W1596598368 hasConcept C2776174256 @default.
• W1596598368 hasConcept C2777391703 @default.
• W1596598368 hasConcept C2778112365 @default.
• W1596598368 hasConcept C2779306644 @default.
• W1596598368 hasConcept C41008148 @default.
• W1596598368 hasConcept C55493867 @default.
• W1596598368 hasConcept C83730767 @default.
• W1596598368 hasConcept C86803240 @default.
• W1596598368 hasConceptScore W1596598368C104292427 @default.
• W1596598368 hasConceptScore W1596598368C104317684 @default.
• W1596598368 hasConceptScore W1596598368C112446052 @default.
• W1596598368 hasConceptScore W1596598368C134018914 @default.
• W1596598368 hasConceptScore W1596598368C139770010 @default.
• W1596598368 hasConceptScore W1596598368C164083038 @default.
• W1596598368 hasConceptScore W1596598368C167625842 @default.
• W1596598368 hasConceptScore W1596598368C170493617 @default.

• next